ORIGINAL ARTICLE

Supplementation 2000mg and 1000mg of linoleic acid and alfa linolenic acid delayed pre diabetic state in Balinese young obese women: A Randomised Clinical Trial

I Wayan Weta , I Wayan Putu Sutirtayasa, Anak Agung N Subawa N Subawa, Safarina G Malik

I Wayan Weta
Department of Community and Preventive Medicine/Department of Clinical Nutrition, Faculty of Medicine, Udayana University/Sanglah Hospital, Denpasar Bali Indonesia.. Email: wy_weta@unud.ac.id

I Wayan Putu Sutirtayasa
Post Graduate Program Faculty of Medicine Udayana University, Denpasar Bali Indonesia

Anak Agung N Subawa N Subawa
Department of Clinical Pathology Faculty of Medicine Udayana University Denpasar Bali Indonesia

Safarina G Malik
Eijkman Institute for Molecular Biology, Ministry of Research Technology and Higher Education, Republic of Indonesia, Jakarta, Indonesia
Online First: August 04, 2017 | Cite this Article
Weta, I., Sutirtayasa, I., Subawa, A., Malik, S. 2017. Supplementation 2000mg and 1000mg of linoleic acid and alfa linolenic acid delayed pre diabetic state in Balinese young obese women: A Randomised Clinical Trial. Bali Medical Journal 6(3): S55-S60. DOI:10.15562/bmj.v3i3.721


Background. Obesity fuelled an epidemic of type 2 diabetes mellitus, globally. Controlling pre diabetic state in an obese person is important to prevent the type 2 diabetes. PUFAs (n-6 and n-3) have a role in controlling insulin resistance. The aim is to elucidate the effect of the linoleic acid (LA) and alfa linolenic acid (ALA) supplementation to fasting plasma glucose in young women obese patients. Material and Method. In totally, 45 young obese women in Denpasar Bali, randomized into two group; 22 participants were supplemented with 2000mg and 1000mg of LA and ALA (Intervention), and 23 participants were given placebo (Control), for 12 weeks. Both groups were recommended to restrict their daily energy intake <1500 kcal, during the study. The data namely; dietary, anthropometric, blood triglyceride, plasma fasting glucose was assessed at baseline and end-line of study. Results. Both groups restricted their energy intake less than 1500 kcal in the end line assessment. All of the body fat parameters (BMI, triglycerides, waist circumference, conicity index, waist to height ratio, and lipid accumulation product; p=0.003, p=0.049, p<0.001, p=0.002, p=0.001, and p= 0.001, respectively) decreased in the Intervention group. However, only the conicity index decreased (p=0.025) in the Control group. In the Intervention group no significant change in fasting plasma glucose, contrary it increased (p=0.007) in the Control group. The impaired plasma glucose increased in the Control group (OR=8, p=0.039), but not in the Intervention group (p=0.508). Conclusion. Restriction energy intake with supplementation 2000mg and 1000mg of LA and ALA control pre diabetes of young obese women.

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