Introduction: The neuro anesthesia technique is the only anesthetic technique used today in craniotomy surgery, the anesthetic doctor must pay attention to the components of CBF and ICP which depends on the hemodynamic parameters of patient. Such condition is influenced by anesthetic drugs used in the technique. Intravenous anesthetic drugs that can decrease ICP and CBF from induction drug classes are thiopental, propofol, etomidate, and midazolam. Aim of this study is to obtain comparison of hemodynamic response after administration of propofol and thiopental as an induction drug in brain surgery with general anesthesia.Methods: Study design using double-blinded randomized clinical trial with a total sample of 40 research subjects performed elective brain surgery using general anesthesia techniques. The sample was divided into two groups, the patients were induced with propofol 2 mg /kg for group A and thiopental 4.5 mg /kg for group B in 1 minute. Measurements of hemodynamic response (systolic blood pressure, diastolic blood pressure, heart rate, mean arterial pressure and RPP score) were tested. The results were tested using independent sample t-test, with a significance level of 95% (p <0.05).Results: The results showed that mean systolic blood pressure, diastolic blood pressure, mean arterial pressure and RPP score between group A and B was significantly different from T1, T2, T3 (p <0,05). Meanwhile, for heart rate, there were no significant differences (p > 0.05).Conclusions: There were significant hemodynamic differences in the administration of thiopental and propofol drugs in brain surgery patients. Thiopental drug administration showed lower systolic blood pressure, diastolic blood pressure and mean arterial pressure compared to propofol for induction drugs.

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