ORIGINAL ARTICLE

Plasma Vascular Endothelial Growth Factor (VEGF) profile and the association with synovial inflammation in knee osteoarthritis

Elysanti Dwi Martadiani , I Ketut Siki Kawiyana, Sianny Herawati, Anastasia Tjan

Elysanti Dwi Martadiani
Diagnostic Radiology Department, Udayana Faculty of Medicine/Sanglah Hospital-Denpasar. Email: elysantidm@gmail.com

I Ketut Siki Kawiyana
Orthopaedic and Traumatology Department, Udayana Faculty of Medicine/Sanglah Hospital-Denpasar

Sianny Herawati
Clinical Pathology Department, Udayana Faculty of Medicine/Sanglah Hospital-Denpasar

Anastasia Tjan
Diagnostic Radiology Department, Udayana Faculty of Medicine/Sanglah Hospital-Denpasar
Online First: October 03, 2018 | Cite this Article
Martadiani, E., Kawiyana, I., Herawati, S., Tjan, A. 2018. Plasma Vascular Endothelial Growth Factor (VEGF) profile and the association with synovial inflammation in knee osteoarthritis. Bali Medical Journal 7(3). DOI:10.15562/bmj.v7i3.1209


Background Recent update of osteoarthritis (OA) pathophysiology is affected by inflammatory process of the synovium, which in turn plays the role in prevention of disease progression. It is believed that vascular endothelial growth factor (VEGF), an essential growth factor for vascular endothelial cells, is engaged in synovial inflammatory process that occurs in knee OA, but the association between circulating VEGF levels with synovial inflammation in knee OA is not well known.

Purpose: Identification of plasma VEGF profile and its association with synovial inflammation in knee OA patients.

Method: Consecutive cross-sectional study of primary knee OA patients with or without synovial inflammation. All research materials from history taking, physical examination, to imaging analysis such as ultrasound as well as measurement of plasma VEGF levels using ELISA were done and analysed using T-test, Spearman correlation test, Pearson correlation test, and multiple linear regression analysis (p= 0.05).

Result: There was significant increase of circulating plasma VEGF level in knee OA patients with synovial inflammation (p<0.05). Synovial inflammation was proven associated with high level of plasma VEGF level and influenced by overweight and degree of knee OA variable (p<0.05), but did not associate with existence of OA in other joints, accept OA therapy, hyperuricemia nor DM (p>0.05).

Conclusion Plasma VEGF levels are higher in knee OA with synovial inflammation, and there is an association between high plasma VEGF levels with the occurrence of synovial inflammation in knee OA.

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