Introduction: Estrogen is known to contribute significantly to the formation and growth of breast tumors. High levels of serum estrogen and long-term exposure to estrogen are associated with an increased risk of breast cancer. The mechanism of estrogen involvement in the process of carcinogenesis is not known for certain. Many things are risk factors for breast cancer, between early menarche, slow menopause, with families with a history of breast cancer, obesity and a high-fat diet, age of upward productivity, first pregnancy in old age, and hormones. The purpose of this study was to see whether there is a long relationship of estradiol exposure to breast cancer grading.
Methods: Study design using cross sectional model, a sample of all breast cancer patients treated in the sub-section of surgical oncology rs dr muwardi March-mei 2016 as many as 108 with the criteria of breast cancer erÎ± positive. Analysis by using Pearson correlation to see the strength of relationship between variables and see the presence or absence of long exposure relationship with grading by using ono-way ANOVA.
Result: 108 samples with ERÎ± positive breast cancer, age 31 - 85 years, with longest exposure >40 years. Age of menarche, history of pregnancy, first childbirth, age of menopause, family history, and grading showed a relationship with prolonged exposure to estradiol, p<0.05. The longer the estradiol exposure of 39.89 years indicates the presence of high grade (grade III), p-value <0.05.Conclusion: The duration of estradiol exposure in breast cancer patients will affect the grading of cancer.