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The combination effect of brisk walking and relaxation toward hs-crp and anxiety levels in subject with central obesity in Singaraja, Bali

Abstract

Background: Inflammation and anxiety have reciprocal relationships because low grade chronic inflammation characterized by elevated hs-CRP in central obesity has been proved to induce anxiety. Likewise, anxiety could also induce central obesity and inflammation of peripheral tissue. Brisk walking and relaxation have been proved to have anti-inflammatory effects. However, the effects of their application in central obesity population have not been observed.

Objective: The aim of the study is to determine the combination effect of brick walking and relaxation on hs-CRP and anxiety level.

Method: This research is an experimental research with randomized controlled trial design. According to sample size formula, this study required 80 with central obesity which would be selected using purposive sampling. The sample was divided into 4 groups by randomization procedure intocontrol group, brisk walking group, relaxation group and combination of brisk walking and relaxation group. Each group was given thrice a week treatment for six weeks. Data were analyzed by using SPSS 22.

Results: A total of 80 samples with central obesity were enrolled with mean age 47.66 ± 7.47 years old and WHtR 0.57 ± 0.04. There is no significant effect of brisk walking, relaxation, and their combination to hs-CRP level (p = 0.696). On the other hand, all of the interventions were significantly reduce the anxiety level. However, the combination of brisk walking and relaxation had the most significant effect in decreasing anxiety level even when compared to either brisk walking or relaxation group (p <0.05).

Conclusion: Both brisk walking and relaxation significantly reduce the level of anxiety but their combination had the most significant effect. However, no intervention had proved to alter the level of hs-CRP.

 

References

  1. Dixon JB. The effect of obesity on health outcomes. Mol Cell Endocrinol. 2010; 316:104–8.
  2. Monteiro R, Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm. 2010.
  3. De Heredia FP, Gómez-Martínez S, Marcos A. Chronic and degenerative diseases: Obesity, inflammation and the immune system. Proc Nutr Soc. 2012;71(2):332–8.
  4. Singh T, Newman AB. Inflammatory markers in population studies of aging. Ageing Res Rev. 2011; 10(3):319-29
  5. Singhal G, Jaehne EJ, Corrigan F, Toben C, Baune BT. Inflammasomes in neuroinflammation and changes in brain function: A focused review. Front Neurosci. 2014; 8:1–22.
  6. Hou R, Garner M, Holmes C, Osmond C, Teeling J, Lau L, et al. Peripheral inflammatory cytokines and immune balance in Generalised Anxiety Disorder: Case-controlled study. Brain Behav Immun. 2017; 62:212–8.
  7. Capuron L, Miller AH. Immune system to brain signalling : Neuropsychopharmacological implications. Pharmacol Ther. 2011;130(2):226–38.
  8. Hsuchou H, Kastin AJ, Mishra PK, Pan W. C-Reactive Protein Increases BBB Permeability: Implications for Obesity and Neuroinflammation. Cell Physiol Biochem. 2012; 30(5):1109–19.
  9. Maes M, Maes M, Kubera M, Obuchowiczwa E, Goehler L, Brzeszcz J. Depression's multiple comorbidities expalined by (neuro) inflammatory and oxidative & nitrosative stress pathways. Neuroendocrinol Lett. 2011; 32(1):7–24.
  10. Gu HF, Tang CK, Yang YZ. Psychological stress, immune response, and atherosclerosis. Atherosclerosis. 2012; 223(1):69–77. http://dx.doi.org/10.1016/j.atherosclerosis.2012.01.021
  11. Tian R, Hou G, Li D, Yuan TF. A possible change process of inflammatory cytokines in the prolonged chronic stress and its ultimate implications for health. Sci World J. 2014;2014.
  12. Abd El-Kader S, Gari A, Salah El-Den A. Impact of moderate versus mild aerobic exercise training on inflammatory cytokines in obese type 2 diabetic patients: a randomized clinical trial. Afr Health Sci. 2013; 13(4):857–63.
  13. Pedersen BK, Brandt C. The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases. J Biomed Biotechnol. 2010.
  14. Benson H, F. Beary J, P. Carol M. The Relaxation Response. Psychiatry. 1974; 37(1):37-46.
  15. Blundell J, Gibbons C, Caudwell P, Finlayson G, Hopkins M. Appetite control and energy balance: Impact of exercise. Obes Rev. 2015; 16 Suppl 1:67-76.
  16. Shrivastava AK, Singh HV, Raizada A, Singh SK. C-reactive protein , inflammation and coronary heart disease. Egypt Hear J. 2015; 67(2):89–97. http://dx.doi.org/10.1016/j.ehj.2014.11.005
  17. Goh J, Goh KP, Abbasi A. Exercise and Adipose Tissue Macrophages: New Frontiers in Obesity Research? Front Endocrinol. 2016; 7:1–8.
  18. Castoldi A, Naffah de Souza C, Câmara NO, Moraes-vieira PM. The Macrophage Switch in Obesity Development. Front Immunol. 2016; 6:637.
  19. Gleeson M, Bishop NC, Stensel DJ, Lindley MR. The anti-inflammatory effects of exercise : mechanisms and implications for the prevention and treatment of disease. Nat Publ Gr. 2011; 11(9):607–15. http://dx.doi.org/10.1038/nri3041
  20. Kawanishi N, Yano H, Yokogawa Y, Suzuki K. Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet- induced obese mice. Exerc Immunol Rev. 2010; 16:105–18.
  21. Koehl M, Meerlo P, Gonzales D, Rontal A, Turek FW, Abrous DN. Exercise-induced promotion of hippocampal cell proliferation requires β-endorphin. FASEB J. 2008; 22(7):2253–62. https://doi.org/10.1096/fj.07-099101
  22. Ataka K, Asakawa A, Nagaishi K, Kaimoto K, Sawada A, Hayakawa Y, et al. Bone Marrow-Derived Microglia Infiltrate into the Paraventricular Nucleus of Chronic Psychological Stress- Loaded Mice. PLoS One. 2013; 8(11):1–14.
  23. Wohleb ES, Mckim DB, Sheridan JF, Godbout JP. Monocyte trafficking to the brain with stress and inflammation : a novel axis of immune-to-brain communication that influences mood and behavior. Front Nerosci. 2015; 8:447.
  24. Cahn BR, Goodman MS, Peterson CT, Maturi R, Mills PJ. Yoga , Meditation and Mind-Body Health : Increased BDNF , Cortisol Awakening Response , and Altered Inflammatory Marker Expression after a 3-Month Yoga and Meditation Retreat. Front Hum Nerosci. 2017; 11:315.
  25. Grundmann O, Yoon SL. Mind – body therapies for functional bowel disorders — A review of recent clinical trials. Eur J Integr Med. 2013; 5(4):296–307. http://dx.doi.org/10.1016/j.eujim.2013.03.007
  26. Li W-J, Yu H, Yang J-M, Gao J, Jiang H, Feng M, et al. Anxiolytic effect of music exposure on BDNFMet/Met transgenic mice. Brain Res. 2010; 1347:71-9.

How to Cite

Purnomo, K. I., Doewes, M., Suroto, S., Murti, B., & Widiastuti Giri, M. K. (2019). The combination effect of brisk walking and relaxation toward hs-crp and anxiety levels in subject with central obesity in Singaraja, Bali. Bali Medical Journal, 8(1), 294–298. https://doi.org/10.15562/bmj.v8i1.1287

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Ketut Indra Purnomo
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Muchsin Doewes
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Suroto Suroto
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Bhisma Murti
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Made Kurnia Widiastuti Giri
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