CASE REPORT

Mutation of the Fas-promoter-670 gene, AA to GA in the normal cervix-epithelial-cells of high risk Indonesian mother: A case report

Mauritius Lambertus Edy Parwanto , Raditya Wratsangka, Assangga Guyansyah, Kirana Anggraeni

Mauritius Lambertus Edy Parwanto
Department of Biology, Faculty of Medicine, University of Trisakti, Indonesia. Email: edyparwanto@trisakti.ac.id

Raditya Wratsangka
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Trisakti, Indonesia

Assangga Guyansyah
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Trisakti, Indonesia

Kirana Anggraeni
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Trisakti, Indonesia
Online First: April 01, 2019 | Cite this Article
Parwanto, M., Wratsangka, R., Guyansyah, A., Anggraeni, K. 2019. Mutation of the Fas-promoter-670 gene, AA to GA in the normal cervix-epithelial-cells of high risk Indonesian mother: A case report. Bali Medical Journal 8(1): 360-364. DOI:10.15562/bmj.v%vi%i.1313


Background: Normalities of the cervix-epithelial-cells (CEC) can be determined base on the cell morphology and their nucleus. If one of the cervix-epithelial-cells has gene mutations, it will form mutant clones, further growing, developing and malignant. The Fas-promoter-670 gene is allegedly associated with cervical cancer.

Case Presentation: A  30-year-old  of high-risk Indonesian mother,  has two children, on April 21th  2016 has followed Pap smear examination with thin prep method. Subjects, in this case, had normal cervix-epithelial-cells. Characteristics of the cervix-epithelial-cells include cell biometrics among others cell length, cell width, cell area, cell perimeter, nucleus area, and nucleus perimeter. Fas-promoter-670 genotype in the lymphocytes-cells is AA (normal= wild type), whereas in the cervix-epithelial-cells is GA (heterozygous mutant).

Conclusion: Based on characteristic of cell biometrics, cervix-epithelial-cells in high-risk Indonesian mother is normal. The genotype of the Fas-promoter-670 gene in the lymphocyte cells is AA, whereas in the cervix-epithelial-cells has mutation to GA.

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