ORIGINAL ARTICLE

Analysis of serum 25-Hydroxyvitamin D level in keloid patients

Vira Indhiratamin Damanik , Imam B Putra, Oratna Ginting

Vira Indhiratamin Damanik
Post graduate of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia. Email: vira.indhira@yahoo.com

Imam B Putra
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

Oratna Ginting
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Online First: April 01, 2009 | Cite this Article
Damanik, V., Putra, I., Ginting, O. 2009. Analysis of serum 25-Hydroxyvitamin D level in keloid patients. Bali Medical Journal 8(1).


Background: Keloid is solid fibrous tissue tumors that occur due to an imbalance between deposition and degradation of extracellular matrix components, especially collagen. Vitamin D is known to have a beneficial role in slowing the progression of tissue fibrosis and proven to play an important role in the synthesis and degradation of collagen and acts as an anti-inflammatory mediator.

Aim: To determine the difference between serum 25-hydroxyvitamin D level in keloid patients and controls.

Method: This is a cross-sectional analytic study involving 60 subjects consist of 30 keloid patients and 30 controls. Keloid patients were diagnosed by history and clinical examinations, and we conducted blood sampling and measurement of serum 25-hydroxyvitamin D level to the patients and controls.

Results: The mean of serum 25-hydroxyvitamin D level in keloid patients (16.92 ± 5.96 ng/mL) was significantly lower than controls (23.57 ± 6.72 ng/mL), p=0.0001

Conclusion: Serum 25-hydroxyvitamin D level in keloid patients was significantly lower than controls, serum 25-hydroxyvitamin D level in keloid patients was higher in the male group, aged 31-35 years group, duration of disease between 6-10 years group and positive family history.

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