ORIGINAL ARTICLE

Correlation between Superoxide Dismutase Level and Disease Activity of Vitiligo

Nelva K Jusuf , Kamaliah Muis, Kharina Y Putri

Nelva K Jusuf
Department of Dermatology and Venereology, Faculty of Medicine, Sumatera Utara University, Medan, Indonesia. Email: nelva_jusuf@yahoo.com

Kamaliah Muis
Department of Dermatology and Venereology, Faculty of Medicine, Sumatera Utara University, Medan, Indonesia

Kharina Y Putri
Post graduate of Dermatology and Venereology, Faculty of Medicine, Sumatera Utara University, Medan, Indonesia
Online First: April 01, 2019 | Cite this Article
Jusuf, N., Muis, K., Putri, K. 2019. Correlation between Superoxide Dismutase Level and Disease Activity of Vitiligo. Bali Medical Journal 8(1): 291-293. DOI:10.15562/bmj.v8i1.1374


Background: Vitiligo is a chronic systemic acquired disease that has an unpredictable clinical course, characterized by the appearance of macules and achromic or hypochromic patches on the skin and mucous membranes due to the disappearance of melanocytes in the affected area. Until now, the underlying pathogenesis of vitiligo is still unclear. The role of superoxide dismutase (SOD) in vitiligo is mentioned that it can be a biomarker to determine vitiligo activity and progressivity.

Aim: To determine correlation between SOD and vitiligo disease activity score (VIDA)

Materials and methods: This study was a cross-sectional analytic study which involved 39 vitiligo patients that were diagnosed by clinical and Wood’s lamp examinations. VIDA score was determined to assess lesion activity, which is categorized in the six-point scale. We conducted blood sampling and measurement of SOD level to the patients by ELISA.

Results: We found mean SOD in +4 group was 37.55 ng/ml, +3 group was 25.32 ng/ml, +2 group was 4.67 ng/ml, +1 group was 5.60 ng/ml, and 0 group was 3.88 ng/ml.  There was is no difference of SOD level based on VIDA score  (p=0.775 r=-0.047). In this study, we found the highest mean SOD level in subjects with vitiligo activity lasting from 6 weeks to 3 months and the lowest level in group with lesion activity stable for 1 year.

Conclusion: There was no significant correlation between SOD and VIDA score in vitiligo patients.

 

References

Tarlé RG, Nascimento LM, Mira MT, Castro CC. Vitiligo--part 1. An Bras Dermatol. 2014 May-Jun;89(3):461-70. doi: 10.1590/abd1806-4841.20142573

Birlea SA, Spritz RA, Noris DA. Vitiligo. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffel DJ, Wolff K,editors. Fitzpatrick's dermatology in general medicine. 8th ed. New York: The MCGraw-Hill companies. 2012:1308-24

Jusuf NK. Pattern of pigmentation disorder in Cosmetic Dermatology Clinic H. Adam Malik General Hospital, Medan, 2012 – 2015. Journal of General- Procedural Dermatology & Venereology Indonesia. 2017;2(1):1-6. doi:10.19100/jdvi.v2i1.46

Benzekri L, Gauthier Y, Hamada S and Hassam B. Clinical features and histological findings are potential indicators of activity in lesions of common vitiligo. BJD. 2012:265–71. doi: 10.1111/bjd.12034

Alghamdi KM, Kumar A,Taieb A, Ezzedine K. Assessment methods for the evaluation of vitiligo. JEADV. 2012. doi: 10.1111/j.1468-3083.2012.0405

Bhor U, Pande S. Scoring systems in dermatology. Indian J Dermatol Venereol Leprol. 2006 Jul-Aug;72(4):315-21. doi: 10.4103/0378-6323.26722

Njoo, Westerhof W. Therapeutic guidelines for vitiligo. In: Lotti T, Hercogova J. Vitiligo problem and solution. New York. Basel. Marcel Dekker. 2004:235-51

Alikhan A, Felsten LM, Daly M, Petronic-Rosic V. Vitiligo: A comprehensiveoverview part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. J Am Acad Dermatol. 2011 Sep;65(3):473-91. doi: 10.1016/j.jaad.2010.11.061

Le Quéré S, Lacan D, Lemaire B, Carillon J, Schmitt K. The role of superoxidedismutase (SOD) in skin disorders A review. Nutrafoods. 2014;13:13-27. doi: 10.1007/s13749-014-0001-x

Putri KY. Superoxide dismutase Level Profile in Vitiligo Patients at H. Adam Malik General Hospital Medan. Article in press, Bali Medical Journal. 2018. doi: 10.15562/bmj.v7i3.1074

Putri KY. Hubungan antara kadar superoxide dismutase dengan skor vitiligo area scoring index pada pasien vitiligo di RSUP Haji Adam Malik Medan, Tesis: Fakultas Kedokteran Universitas Sumatera Utara. 2018. (Indonesian)

Sudarsa PSS. Kadar Superoxide Dismutase Dalam Darah Berkorelasi Positif Dengan Derajat Keparahan Dan Aktivitas Penyakit Vitiligo, Skripsi : Fakultas Kedokteran Universitas Sumatera Utara. 2015. (Indonesian)


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