ORIGINAL ARTICLE

The role of serum albumin level within the first 24-hours of hospitalization to the mortality risk in burn patients at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia

Ummi Muthiah , Tiene Rostini, Nina Tristina

Ummi Muthiah
Resident of Department of Clinical Pathology, Faculty of Medicine, Padjadjaran University, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Email: ummi.muthiah@gmail.com

Tiene Rostini
Department of Clinical Pathology, Faculty of Medicine, Padjadjaran University, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.

Nina Tristina
Department of Clinical Pathology, Faculty of Medicine, Padjadjaran University, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
Online First: August 01, 2019 | Cite this Article
Muthiah, U., Rostini, T., Tristina, N. 2019. The role of serum albumin level within the first 24-hours of hospitalization to the mortality risk in burn patients at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Bali Medical Journal 8(2). DOI:10.15562/bmj.v8i2.1402


Introduction: Serum albumin level may predict the mortality risk in burn patients. This study aimed to determine the mortality risk in burn patients based on serum albumin level within the first 24 hours of hospitalization.

Method: A cross sectional study was conducted reprostecively to the patient’s medical records. The subjects were burned patients who were hospitalized in Dr. Hasan Sadikin General Hospital Bandung during January-December 2017. The subjects were divided into two groups, which were dead and survived at the end of hospitalization. The mortality risk based on serum albumin level within the first 24 hours of admission was assessed using the odds ratio (OR) of two groups. Data were analyzed using SPSS version 17 for windows.

Result: The subjects were 47 patients, consisted of 9 dead subjects and 38 survived subjects. Males were predominant in both groups such as 12.8% in dead subjects and 70.2% in survived subjects. The OR value based on serum albumin level <2 g/dL within the first 24 hours of hospitalization was 14.40 (p=0.009; CI:2.1–100).

Conclusion: The subjects with serum albumin level <2 g/dL within 24 hours of hospitalization has 14 times higher mortality risk compared to the subjects with serum albumin level >2 g/dL. Therefore, burn patients need to be examined for serum albumin level within the first 24 hours of hospitalization.

References

World Health Organization (WHO). World Health Organization Burns. 2018. [Accessed 24 December 2018]. Available on http://www.who.int/en/news-room/fact-sheets/detail/burns

Wardhana A, Basuki A, Prameswara ADH, Rizkita DN, Andarie AA, Canintika AF. The epidemiology of burn in Indonesia's National refferal burn center from 2013 to 2015. Burns Open. 2017; 1:67-73.

Indonesian Ministry of Health. Report of National Basic Health Research (RISKESDAS) 2013. Jakarta: 2014.

Aguayo-Becerra OA, Torres-Garibay C, Macias-Amezcua MD, Fuentes-Orozco C, Chaves-Tostado MdG, Andalon-Duenas E, et al. Serum albumin level as a risk factor for mortality in burn patients. Clinics. 2013; 68(7):940-5.

Kim GH, Oh KH, Yoon JW, Koo JR, Kim HJ, Chae DW et al. Impact of burn size and initial serum albumin level on acute renal failure occuring in major burn. Am J Nephrol. 2003; 23(1):55-60.

Eljajek R, Dubois M. Hypoalbuminemia in the first 24h of admission is associated with organ dysfunction in burned patients. Burns. 2013; 39(1):113-8.

Deepthi S, Narayan GAR. Evaluation of serum albumin levels and its relation to burn size in burn patients. World Journal of Pharmacy and Pharmaceuttical Sciences. 2015;4(8):1461-5.

Bhansali CA, Gandhi G, Sahastrabudhe P, Panse N. Epidemiological study of burn injuries and its mortality risk factors in a tertiary care hospital. Indian J Burns. 2017;25:62-6.

Jeschke MG, Gauglitz GG, Kulp GA, Finnerty CC, Williams FN, Kraft R et al. Long-term persistance of the pathophysiologic response to severe burn injury. PLoS ONE. 2011;6(7):e21245.

Karlie J, Wardhana A. External validation of belgian outcome of burn injury score on burned patient in burn unit Cipto Mangunkusumo general hospital. New Ropanasuri J Surg. 2017;2(1):e90.

Li H, Yao Z, Tan J, Zhou J, Li Y, Wu Y et al. Epidemiology and outcome analysis of 6325 burn patients: a five-year retrospective study in a major burn center in southwest china. Sci Rep. 2017; 7:46066.

Burhan AS, Muljono, Syamsuddin E. Alat Pencegahan Kebakaran yang Disebabkan Kebocoran Liquefied Petroleum Gas (LPG). TESLA. 2013; 15(2):153-64.

Yasti AC, Senel E, Saydam M, Ozok G, Coruh A, Yorganci K. Guideline and treatment algorithm for burn injuries. Ulus Travma Acil Cerrahi Derg. 2015; 21(2):79-89

Iftimia N, Ferguson RD, Mujat M, Patel AH, Zhang EZ, Fox W et al. Combined reflectance confocal microscopy/optical coherence tomography imaging for skin burn assessment. Biomedical Opt Express. 2013; 4(5):680-95

Udy AA, Roberts JA, Lipman J, Blot S. The effects of major burn related pathophysiological changes on the pharmacokinetics and pharmacodynamics of drug use: An appraisal utilizing antibiotics. Adv Drug Deliv Rev. 2018; 123:65-74

Lopez ON, Cambiaso-Daniel J, Branski LK, Norbury WB, Herndon DN. Predicting and managing sepsis in burn patients: current perspectives. Ther Clin Risk Manag. 2017; 13:1107-1117

Clark A, Imran J, Madni T, Wolf SE. Nutrition and metabolism in burn patients. Burns Trauma. 2017; 5(11):1-12.


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