ORIGINAL ARTICLE

The effect of Sargassum duplicatum extract on SGPT level in Rattus norvegicus infected by Plasmodium berghei

Herin Setianingsih , Dimas Bathoro Bagus Pamungkas, Prawesty Diah Utami

Herin Setianingsih
Department of Anatomy, Medical Faculty, Universitas Hang Tuah, Surabaya. Email: herin.setianingsih@hangtuah.ac.id

Dimas Bathoro Bagus Pamungkas
Department of Anatomy, Medical Faculty, Universitas Hang Tuah, Surabaya

Prawesty Diah Utami
Department of Parasitology, Medical Faculty, Universitas Hang Tuah, Surabaya
Online First: August 01, 2019 | Cite this Article
Setianingsih, H., Pamungkas, D., Utami, P. 2019. The effect of Sargassum duplicatum extract on SGPT level in Rattus norvegicus infected by Plasmodium berghei. Bali Medical Journal 8(2). DOI:10.15562/bmj.v8i2.1485


Background: Malaria still becomes a major health problem in Indonesia, especially in the eastern part of Indonesia. The occurrence of Plasmodium resistance against antimalarial medications increases the difficulty of malaria wipe-out effort. As regard with such a great potential Sargassum production that Indonesia possesses, it is very likely to develop Sargassum as adjuvant therapy to prevent and even to stop the resistance.

Aim: This research aims to develop adjuvant therapy of Sargassum extract to avoid the resistance of malaria therapy on the SGPT level.

Method: There were 24 white rats (Rattus norvegicus) that had been infected by Plasmodium berghei and were given dihydroartemisinin-piperaquin (DHA-PPQ) therapy as antimalarial therapy at the dose of 3mg/KgBW for three consecutive days. The rats were later divided into three groups. Group 1 received only (DHA-PPQ), group 2 received Sargassum duplicatum extract as adjuvant therapy at  the dose of 100 mg/KgBW for ten consecutive days. Group 3 also received Sargassum duplicatum extract as adjuvant therapy but the dose was at 300 mg/KgBW for ten consecutive days.

Result: SGPT level decreased more significantly in groups in which the rats received dihydroartemisinin-piperaquine and 100 mg/kgBW Sargassum extract as adjuvant therapy and on the other hand only received Sargassum extract at the dose of 300 mg/kgBW. After ten days of therapy the blood SGPT level was examined from all rats. The data were analyzed using one-way ANOVA test.

Conclusion: Sargassum duplicatum (100 mg/kgBW) showed a more significant decrease of SGPT level in Rattus norvegicus (Wistar strain) inoculated by Plasmodium berghei as against those in the dose 300 mg/kgBW. 

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