Skip to main content Skip to main navigation menu Skip to site footer

Correlation between the level of interleukin-6 serum and blood peripheral leukocyte in patients with severe traumatic brain injury


Background: Increased level of interleukin 6 (IL-6) in patients with severe traumatic brain injury (TBI) has been documented, yet studies of its ability to predict the outcome based on the Leukocyte is limited and lacks clarity. This study aims to evaluate the relationship between serum level of IL 6 and Leukocyte among patients with severe TBI.

Methods: Twenty patients admitted consecutively to the emergency room (ER) with severe TBI were included in this observational, cross-sectional, single-centre study. Venous blood sample for IL 6 and leukocyte was performed less than 24 hours of trauma in the Intensive Care Unit.  Age and gender were also recorded. Variable selection was run in stepwise forward fashion. Correlational odds models were conducted to assess how change in Leukocyte is related to levels of IL 6. Data were analysed using SPSS version 17 for Windows.

Results: The average age of respondents was 32.45±10.71 years old and mostly males (85%). The Glasgow Coma Scale (GCS) was predominant in score 8 (45%). The mean value of IL-6 was 22.00±4.66 pg/ml and 22.53±8.11 x 103 in leucocyte. The weak insignificant correlation was found between IL-6 and blood peripheral leucocyte using Pearson Correlation test (r = - 0.290; p = 0.108)

Conclusion: The recent findings suggest that there is no correlation between IL 6 levels and Leukocyte in patients with severe TBI.


  1. Norton JA, Barie PS. Traumatic Brain Injury. In: Surgery Basic Science and Clinical Evidence. 2nd Edition. 2008:461.
  2. Tjahjadi M, Arifin MZ, Gill AS, Faried A. Early mortality predictor of severe traumatic brain injury: A single center study of prognostic variables based on admission characteristics. Ind J of Neurotrauma. 2013;10(1):3-8.
  3. Yousefzadeh-Chabok S, Dehnadi Moghaddam A, Kazemnejad-Leili E, Saneei Z, Hosseinpour M, Kouchakinejad-Eramsadati L, et al. The Relationship Between Serum Levels of Interleukins 6, 8, 10 and Clinical Outcome in Patients With Severe Traumatic Brain Injury. Arch Trauma Res. 2015;4(1):e18357.
  4. Rothaug M, Becker-Pauly C, Rose-John S. The Role of Interleukin 6 Signaling in nervous tissue. Biochim Biophys Acta. 2016;1863(6 Pt A):1218-27.
  5. Sabir S, Umer N, Shoaib M, Zulfiqar S. Correlation of Interleukin-10 with Glasgow Coma Scale in Patients of Stroke. Pakistan Journal of Medical and Health Sciences. 2016;10(1):63-65
  6. Chesnut RM, Ghajar J, Maas AIR, Marion DW. Early indicators of prognosis in severe traumatic brain injury. Journal of Neurotrauma. 2000;17(6):555-627.
  7. Gürkanlar D1, Lakadamyali H, Ergun T, Yilmaz C, Yücel E, Altinörs N. Predictive value of leucocytosis in head trauma. Turk Neurosurg. 2009;19(3):211-5.
  8. La-Placa MC. Manual of traumatic brain injury. In: Essential concepts in TBI biomechanics and Neuropathology. 2nd Edition. New York: Demos Medical. 2016: 10-7.
  9. Hergenroeder GW, Moore AN, McCoy JP Jr, Samsel L, Ward NH 3rd, Clifton GL, et al. Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury. J Neuroinflammation. 2010;7:19.
  10. Marmarou A. A review of progress in understanding the pathophysiology and treatment of brain edema. Neurosurg Focus. 2007;22(5):E1
  11. Härtl R, Medary MB, Ruge M, Arfors KE, Ghajar J. Early white blood cell dynamics after traumatic brain injury: effects on the cerebral microcirculation. J Cereb Blood Flow Metab. 1997;17(11):1210-20.
  12. Rovlias A, Kotsou S. The blood leukocyte count and its prognostic significance in severe head injury. Surg Neurol. 2001;55(4):190-6.
  13. Subramanian PS. Traumatic brain injury in children: how does it affect the eye and vision?. Journal of AAPOS. 2018; 22(6):413-414
  14. Shichita T, Ito M, Yoshimura A. Post-ischemic inflammation regulates neural damage and protection. Front Cell Neurosci. 2014;8:319.
  15. Liu YW, Li S, Dai SS. Neutrophils in traumatic brain injury (TBI): friend or foe?. Journal of Neuroinflammation. 2018;15:146

How to Cite

Bangun, E. C., Prasetyo, E., & Oley, M. C. (2019). Correlation between the level of interleukin-6 serum and blood peripheral leukocyte in patients with severe traumatic brain injury. Bali Medical Journal, 8(3), SS784-S787.




Search Panel

Edwin Calvin Bangun
Google Scholar
BMJ Journal

Eko Prasetyo
Google Scholar
BMJ Journal

Maximillian Christian Oley
Google Scholar
BMJ Journal