ORIGINAL ARTICLE

Correlation between heart failure score and estimation glomerulus filtration rate based on cystatin C in children

Linda Silvana Sari , Eka Gunawijaya, Bagus Ngurah Putu Arhana, Ni Putu Venny Kartika Yantie

Linda Silvana Sari
Department of Child Health, Faculty of Medicine, Universitas Mataram, West Nusa Tenggara, Indonesia. Email: lindasilvanasari@gmail.com

Eka Gunawijaya
Department of Child Health, Faculty of Medicine, Universitas Udayana/Sanglah General Hospital, Denpasar, Bali, Indonesia

Bagus Ngurah Putu Arhana
Department of Child Health, Faculty of Medicine, Universitas Udayana/Sanglah General Hospital, Denpasar, Bali, Indonesia

Ni Putu Venny Kartika Yantie
Department of Child Health, Faculty of Medicine, Universitas Udayana/Sanglah General Hospital, Denpasar, Bali, Indonesia
Online First: December 30, 2019 | Cite this Article
Sari, L., Gunawijaya, E., Arhana, B., Yantie, N. 2019. Correlation between heart failure score and estimation glomerulus filtration rate based on cystatin C in children. Bali Medical Journal 8(3). DOI:10.15562/bmj.v8i3.1583


Background: Heart failure is a clinical syndrome due to decreased cardiac output affecting body perfusion, including the kidneys. An acute or chronic relationship between the heart and the kidney is called cardiorenal syndrome. Cardiorenal syndrome worsens the clinical state and prognosis of patients with heart failure. This study aimed to analyse correlation heart failure score and estimate GFR based on cystatin C.

Methods: This cross-sectional with a study subject of children aged 0-12 years with a diagnosis of heart failure caused by congenital and acquired heart disease. The data were recruited consecutively in the children emergency room with the period January 2016 to July 2017. The decrease in cardiac output was enforced based on cardiac failure score according to modification of Ross when arrived at the hospital and followed by determining the estimated GFR based on cysC base on formula 75.94/CysC1.178 mg/dl. Correlation between heart failure score and estimated GFR was tested using Spearman correlation.

Results: Forty-one subjects were analysed, had median heart failure score 10 (minimum/min 7, maximum/max 12). Median estimate GFR based on cysC 81.65 (min 12.31, max 133.23) ml/minute/1.73m2. There was a moderate negative association between heart failure score and estimated GFR based on cystatin C (r= -0.53; p<0.001).

Conclusion: A moderate negative correlation between heart failure score and estimated glomerular filtration rate based on cystatin C levels in children.

 

References

Daphne TH, Gail D, Pearson MD. Heart failure in children. Circ Heart Failure. 2009;2:490-98. doi: 10.1161/CIRCHEARTFAILURE.108.820217.

Olowu WA. Epidemiology pathophysiology clinical characteristic and management of childhood cardiorenal syndrome. World J Nephrol. 2012;1:16-24. doi: 10.5527/wjn.v1.i1.16.

Liu PP. Cardiorenal syndrome in heart failure: A cardiologist’s perspective. The Canadian Journal of Cardiology. 2008;24:25-9.

Ataei N, Bazargani B, Ameli S, Madani A, Dafadilarijani F, Monthaderi AA. Early detection of acute kidney injury by serum cystatin C in critically children. Pediatr Neprol. 2014;29:133-8. doi: 10.1007/s00467-013-2586-5.

Chung MY. Diagnostic value of Cystatin C for predicting acute kidney injury in patient with liver cirrhosis. The Korean Journal of Hepatology. 2010;16:301-17. doi: 10.3350/kjhep.2010.16.

Zappitelli M, Pervex P, Joseph L, Paradis G, Grey P, Lou S. Derivation and validation of cystatin C based prediction equations for GFR in children. American Journal of Kidney Disease. 2006;2:221-30. DOI: https://doi.org/10.1053/j.ajkd.2006.04.08.

Medar SS, Hsu DP, Jacqueline M, Lamour M.D, Aidin, S. Acute kidney injury in pediatric acute decompensated heart failure. Pediatric Critical Care Medicine. 2015;16:535-41. doi: 10.1097/PCC.0000000000000412.

Park MK. The pediatric cardiology handbook ed 5th. Philadelphia: Mosby Elsevier. 2010:257-60.

Cody RJ, Ljungman S, Covit AB, Kubo SH, Sealey JE, Pondolfino K, Cark M, James G. Regulation of glomerular filtration rate in chronic congestive heart failure patients. International Society of Nephrology. 1988;34:361-7. doi:10.1038/ki.1988.189.

Guglin M, Rivero A, Matar F, Gracia M. Renal dysfunction in heart failure is due to congestion but not low output. Clin Cardio. 2015;34:113-6. doi: 10.1002/clc.20831.

Ross RD. The ross classification for heart failure in children after 25 years: a review an age-stratified revision. Pediatr Cardiol. 2012;33:1295-300. doi:10.1007/s00246-012-0306-8


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