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The correlation of High-Density Lipoprotein (HDL) with adiponectin levels among obese adolescents in Denpasar, Bali, Indonesia

  • Ni Luh Gede Wahyuni ,
  • I Made Arimbawa ,
  • I Made Kardana ,
  • Ketut Suarta ,
  • I Wayan Dharma Artana ,
  • I Gusti Agung Ngurah Sugitha Adnyana ,

Abstract

Background: Obesity is a state of Body Mass Index (BMI) above or equal to 25 kg/m2. In obesity, dyslipidaemia can occur alone or together with other comorbid. This situation could affect pro-inflammatory and anti-inflammatory cytokines that lead to health problems. Several parameters assessed in dyslipidaemia conditions include High-Density Lipoprotein (HDL) and adiponectin. This study aims to evaluate the correlation between HDL and adiponectin levels in obese adolescents. 

Methods: A cross-sectional observational study was conducted among 33 obese adolescence (0-18 years) who met the inclusion criteria at Junior and Senior High School in Denpasar during August 2018-January 2019 period. Variables evaluated in this study were age, sex, weight, height, BMI, HDL, and adiponectin. The correlation assessment of HDL and adiponectin levels was conducted by Partial Correlation test after controlling age and sex using SPSS version 23 for Windows. 

Results: Males (66.70%) were predominant than females (33.30%) with a ratio of 2:1. The average age of respondents was 15.51±0.70 years old. The mean body weight was 91.04±15.40 kilograms, followed by height (163.09±7.40 cm), BMI (34.08±3.90 kg/m2), HDL (43.40±8.00 mg/dl), and adiponectin (4.55±2.1 µg/ml). There was a very weak and not significant correlation by Partial correlation test (r=0.143; p=0.444) between HDL and adiponectin levels.

Conclusion: Our study found There was a very weak and not significant correlation between HDL and adiponectin levels among obese adolescent in Denpasar, Bali, Indonesia

References

  1. Kopin L, Lowenstein C. Dyslipidemia. Ann Intern Med. 2017;167(11):ITC81–ITC96.
  2. Raal FJ. Pathogenesis and management of the dyslipidemia of the metabolic syndrome. Metab Syndr Relat Disord. 2009;7(2):83–88.
  3. Esteve E, Ricart W, Fernández-Real JM. Dyslipidemia and inflammation: an evolutionary conserved mechanism. Clin Nutr. 2005;24(1):16–31.
  4. Ziemke F, Mantzoros CS. Adiponectin in insulin resistance: lessons from translational research. Am J Clin Nutr. 2010;91(1):258S–261S.
  5. Kuczmarski RJ, Ogden CL, Guo SS, et al. 2000 CDC Growth Charts for the United States: methods and development. Vital Health Stat 11. 2002;(246):1–190.
  6. Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med. 1997;337(13):869–873.
  7. Dewi MR, Sidiartha GL. Prevalensi dan faktor risiko obesitas anak sekolah dasar di daerah urban dan rural. Medicina 2013;44(4):15-21.
  8. Ghomari-Boukhatem H, Bouchouicha A, Mekki K, Chenni K, Belhadj M, Bouchenak M. Blood pressure, dyslipidemia and inflammatory factors are related to body mass index in scholar adolescents. Arch Med Sci. 2017;13(1):46–52.
  9. Kern PA, Di Gregorio GB, Lu T, Rassouli N, Ranganathan G. Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression. Diabetes. 2003;52(7):1779–1785.
  10. Ohashi K, Ouchi N, Matsuzawa Y. Anti-inflammatory and anti-atherogenic properties of adiponectin. Biochimie. 2012;94(10):2137–2142.
  11. Lee B, Shao J. Adiponectin and energy homeostasis. Rev Endocr Metab Disord. 2014;15(2):149–156.
  12. Hendarto A. Small Dense Low-Density Lipoprotein sebagai prediktor risiko penyakit jantung koroner pada anak lelaki obes pra-pubertal. Sari Pediatri 2010;12(3):197-203.
  13. Daniele A, Cammarata R, Masullo M, Nerone G, Finamore F, D’Andrea M, et al. Analysis of adiponectin gene and comparison of its expression in two different pig breeds. Obesity (Silver Spring). 2008;16(8):1869–1874.
  14. Magge SN, Stettler N, Koren D, Katz LEL, Gallagher PR, Mohler ER, et al. Adiponectin is associated with favorable lipoprotein profile, independent of BMI and insulin resistance, in adolescents. J Clin Endocrinol Metab. 2011;96(5):1549–1554.
  15. De Rosa A, Monaco ML, Capasso M, Forestieri P, Pilone V, Nardelli C, et al. Adiponectin oligomers as potential indicators of adipose tissue improvement in obese subjects. Eur J Endocrinol. 2013;169(1):37–43.
  16. Nemet D, Wang P, Funahashi T, Matsuzawa Y, Tanaka S, Engelman L, et al. Adipocytokines, body composition, and fitness in children. Pediatr Res. 2003;53(1):148–152.
  17. Thompson TE. Lipid. In: Encyclopaedia Britannica. Encyclopaedia Britannica, Inc. 2006 [cited February 2018] [Available from: https://www.britannica.com/science/lipid/classification-and-formation]
  18. Brambilla P, Antolini L, Street ME, Giusani M, Galbiati S, Valsechi MG, et al. Adiponectin and hypertension in normal-weight and obese children. Am J Hypertens. 2013;26(2):257–264.
  19. Savolainen MJ. Epidemiology: disease associations and modulators of HDL-related biomarkers. Handb Exp Pharmacol. 2015;224:259–283.
  20. Eslamian M, Mohammadinejad P, Aryan Z, Nakhjavani M, Esteghamati A. Positive Correlation of Serum Adiponectin with Lipid Profile in Patients with Type 2 Diabetes Mellitus is Affected by Metabolic Syndrome Status. Arch Iran Med. 2016;19(4):269–274.
  21. Atwa M, Emara A, Balata M, Youssef N, Bayoumy N, Sherif A, et al. Serum leptin, adiponectin, and resistin among adult patients with acanthosis nigricans: correlations with insulin resistance and risk factors for cardiovascular disease. Int J Dermatol. 2014;53(10):e410–e420.
  22. Klünder-Klünder M, Flores-Huerta S, García-Macedo R, Peralta-Romero J, Cruz M. Adiponectin in eutrophic and obese children as a biomarker to predict metabolic syndrome and each of its components. BMC Public Health. 2013;13:88.
  23. Kopelman PG. Obesity as a medical problem. Nature. 2000;404(6778):635–643.
  24. Rashid S, Genest J. Effect of obesity on high-density lipoprotein metabolism. Obesity (Silver Spring). 2007;15(12):2875–2888.
  25. Klop B, Elte JW, Cabezas MC. Dyslipidemia in obesity: mechanisms and potential targets. Nutrients. 2013;5(4):1218–1240.
  26. Wang H, Peng DQ. New insights into the mechanism of low high-density lipoprotein cholesterol in obesity. Lipids Health Dis. 2011;10:176.
  27. Wang ZV, Scherer PE. Adiponectin, the past two decades. J Mol Cell Biol. 2016;8(2):93–100.
  28. Artha IMJR, Bhargah A, Dharmawan NK, Pande UW, Triyana KA, Mahariski PA, et al. High level of individual lipid profile and lipid ratio as a predictive marker of poor glycemic control in type-2 diabetes mellitus. Vasc Health Risk Manag. 2019;15:149–157.
  29. Mulyani WRW, Sanjiwani MID, Sandra, Prabawa IPY, Lestari AAW, Wihandani DM, et al. Chaperone-Based Therapeutic Target Innovation: Heat Shock Protein 70 (HSP70) for Type 2 Diabetes Mellitus. Diabetes Metab Syndr Obes. 2020;13:559–568.

How to Cite

Wahyuni, N. L. G., Arimbawa, I. M., Kardana, I. M., Suarta, K., Artana, I. W. D., & Adnyana, I. G. A. N. S. (2020). The correlation of High-Density Lipoprotein (HDL) with adiponectin levels among obese adolescents in Denpasar, Bali, Indonesia. Bali Medical Journal, 9(1), 286–290. https://doi.org/10.15562/bmj.v9i1.1630

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Ni Luh Gede Wahyuni
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I Made Arimbawa
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I Made Kardana
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Ketut Suarta
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I Wayan Dharma Artana
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I Gusti Agung Ngurah Sugitha Adnyana
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