ORIGINAL ARTICLE

Investigation of Astaxanthin effect on the formation of collagen fibers for periodontal tissue repair in bacteria infected periodontitis

Widia Susanti , Bambang Purwanto, Risya Cilmiaty, Adi Prayitno

Widia Susanti
Doctorate Student of Medical Science Programme, Faculty of Medicine, Universitas Sebelas Maret, Solo, Central Java, Indonesia Departement of Dentistry, Faculty of Medicine, Universitas Sebelas Maret, Solo, Central Java, Indonesia. Email: widiasusanti@staff.uns.ac.id

Bambang Purwanto
Departement of Internal Medicine, Faculty of Medicine Universitas Sebelas Maret, Solo, Central Java, Indonesia Doctorate Medical Science Programme, Faculty of Medicine, Universitas Sebelas Maret, Solo, Central Java, Indonesia

Risya Cilmiaty
Departement of Dentistry, Faculty of Medicine, Universitas Sebelas Maret, Solo, Central Java, Indonesia Doctorate Medical Science Programme, Faculty of Medicine, Universitas Sebelas Maret, Solo, Central Java, Indonesia Departement of Dentistry, Faculty of Medicine, Sebelas Maret Academic Hospital, Solo, Central Java, Indonesia

Adi Prayitno
Departement of Dentistry, Faculty of Medicine, Universitas Sebelas Maret, Solo, Central Java, Indonesia Doctorate Medical Science Programme, Faculty of Medicine, Universitas Sebelas Maret, Solo, Central Java, Indonesia
Online First: August 01, 2020 | Cite this Article
Susanti, W., Purwanto, B., Cilmiaty, R., Prayitno, A. 2020. Investigation of Astaxanthin effect on the formation of collagen fibers for periodontal tissue repair in bacteria infected periodontitis. Bali Medical Journal 9(2): 493-495. DOI:10.15562/bmj.v9i2.1770


Introduction: Periodontitis is an inflammation of periodontal tissue in which the attachment-forming ligament composed of collagen fibers is damaged. Inflammation is a scenario where oxidative stress is abundant which may worsen periodontitis. Antioxidant, such as astaxanthin, is needed to promote collagen fibers formation as a sign of healing.

Objective: To explore whether astaxanthin has a desirable effect in the formation of collagen fibers in bacteria-triggered periodontitis in rats.

Methods: An animal experimental study were conducted. There were 3 groups, each consisted of 8 rats: negative control, positive control, and treated group. The treated group received oral preparation of astaxanthin 0,54 mg/kg/day for 7 days. The rats were then sacrificed, and the periodontal tissue were made into paraffin-fixed 5 µm tick slides with hematoxylin eosin staining and trichromone masson to evaluate the collagen expression. The evaluation was carried out by a pathologist.

Results: There is a significant difference of collagen expression level between the T and PC groups (p-value<0.05)

Conclusion: There is a significant difference between the groups treated with astaxanthin and the group with periodontitis disease.

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