Case report of Laryngeal Amyloidosis: Unusual cause of hoarseness

Noraimi Khamalrudin , Mohd Razif Mohamad Yunus, Marina Mat Baki, Foong Seong Kin

Noraimi Khamalrudin
Otorhinolaryngology Department, Pusat Perubatan Universiti Kebangsaan Malaysia. Email:

Mohd Razif Mohamad Yunus
Otorhinolaryngology Department, Pusat Perubatan Universiti Kebangsaan Malaysia

Marina Mat Baki
Otorhinolaryngology Department, Pusat Perubatan Universiti Kebangsaan Malaysia

Foong Seong Kin
Otorhinolaryngology Department, Pusat Perubatan Universiti Kebangsaan Malaysia
Online First: April 28, 2021 | Cite this Article
Khamalrudin, N., Mohamad Yunus, M., Mat Baki, M., Kin, F. 2021. Case report of Laryngeal Amyloidosis: Unusual cause of hoarseness. Bali Medical Journal 10(1): 211-213. DOI:10.15562/bmj.v10i1.1795

Background: Laryngeal amyloidosis is a rare pathology of the airway in which the diagnosis can only be made via tissue biopsy. We reported a case of laryngeal amyloidosis presenting with symptoms of hoarseness and voice fatigue.

Case report: This is a case report of laryngeal amyloidosis in a middle-aged female patient who presented with hoarseness of voice. Upon obtaining a further history and performing a clinical examination, it was noted that the patient had a laryngeal mass. She underwent surgery, and the mass was histopathologically confirmed as laryngeal amyloidosis. She was successfully treated with a combination of surgical and medical treatment. This case presentation describes these rare pathological findings, their clinical manifestations, the histopathological and surgical diagnostic problems, treatment and patient’s progress that we followed up till presence.

Conclusion: Isolated laryngeal amyloidosis is a rare benign laryngeal tumor that is often presented with various symptoms depending on the tumor location and can even cause upper airway obstruction. It is a histological diagnosis confirmed by histopathological specimens that are stained with Congo red. Treatment of laryngeal amyloidosis includes symptomatic relief, surgical or even conservative treatment. 


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