Dynamics of Human Mesenchymal Stem Cells, M1 Microglia/Macrophage, and Fractalkine in Ischemic Stroke Patients

Lucia Herminawati , Andi Wijaya, Mansyur Arief, Suryani As’ad

Lucia Herminawati
Hasanuddin University Prodia Diagnostic Line. Email: lucia.herminawati@proline.co.id

Andi Wijaya
Prodia Clinical Laboratory, Indonesia

Mansyur Arief
Prodia Clinical Laboratory, Indonesia

Suryani As’ad
Prodia Clinical Laboratory, Indonesia
Online First: April 29, 2016 | Cite this Article
Herminawati, L., Wijaya, A., Arief, M., As’ad, S. 2016. Dynamics of Human Mesenchymal Stem Cells, M1 Microglia/Macrophage, and Fractalkine in Ischemic Stroke Patients. Bali Medical Journal 5(1): 56-58. DOI:10.15562/bmj.v5i1.201

Background: About 85% of strokes are ischemic strokes, caused by occlusion of cerebral artery that induced brain inflammation. A deep understanding of ischemic stroke mechanism will lead to better neurorestorative treatment. Objective: This study investigates the dynamics of human mesenchymal stem cells, fractalkine, and M1 microglia/macrophage in ischemic stroke patients. Results: We found the same fractalkine levels and M1 microglia/macrophage cells on patients with stroke onset 0 to 14 days, then decrease until 30 days of stroke onset. MSCs was increase 7 days after stroke onset, peaked by 14 days, then decreased until 30 days after stroke ischemic onset. Conclusions: This study found an interaction between microglia/macrophage, fractalkine, and MSCs on ischemic stroke patients, so therapeutic strategy could be developed.


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