High serum interleukin-2 levels are associated with pruritus in chronic kidney disease undergoing regular hemodialysis

Luh Made Mas Rusyati , Yenny Kandarin, Ni Nyoman Tri Priliawati

Luh Made Mas Rusyati
Dermatology and Venereology Department, Faculty of Medicine, Universitas Udayana-Sanglah General Hospital, Bali-Indonesia. Email: rusyati@unud.ac.id

Yenny Kandarin
Internal Medicine Department, Faculty of Medicine, Universitas Udayana-Sanglah General Hospital, Denpasar, Bali-Indonesia

Ni Nyoman Tri Priliawati
Dermatology and Venereology Department, Faculty of Medicine, Universitas Udayana-Sanglah General Hospital, Bali-Indonesia
Online First: October 20, 2020 | Cite this Article
Rusyati, L., Kandarin, Y., Priliawati, N. 2020. High serum interleukin-2 levels are associated with pruritus in chronic kidney disease undergoing regular hemodialysis. Bali Medical Journal 9(3): 672-675. DOI:10.15562/bmj.v9i3.2018

Background: Uremic pruritus or more accurately termed ‘chronic kidney disease-associated pruritus’ (CKD-aP) is chronic itch in patients with advanced or end-stage renal disease without evidence of any other active disease that could explain the pruritus. The pathogenesis of CKD-aP is complex and not fully clarified. Some preliminary studies indicate that CKD-aP is a systemic inflammatory disease with a deranged balance of T helper (TH) cell differentiation toward TH1 predominance especially IL-2. This study aimed to elucidate further the association of interleukin-2 serum levels with CKD-aP in patients undergoing regular hemodialysis (HD).

Methods: This was an analytical cross-sectional study. Sampling was taken with consecutive sampling technique. This study was carried out on 72 patients on regular HD consist of 36 patients with CKD-aP and 36 patients without CKD-aP after meeting the inclusion and exclusion criteria. Blood samples were obtained at Hemodialysis Unit Sanglah General Hospital and IL-2 serum levels were measured at Clinical Pathology Laboratory Sanglah General Hospital Denpasar between July 2019 and August 2019. Mann-Whitney U Test was used to compare IL-2 serum between CKD-aP and non-CKD-aP group.

Results: Results in this study we found higher median IL-2 level (17.1 ng/l) on pruritus group versus those without pruritus (13 ng/mL) (p<0.05).

Conclusion: IL-2 serum levels on CKD-aP patients are higher than those without CKD-aP in patients who undergo regular hemodialysis.


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