ORIGINAL ARTICLE

The effect of Myrmecodia pendans extract toward gastric histology in white rats treated with toxic dose of gentamicin: a preliminary report

I Made Bagus Januar Bahari Putra, Ketut Budiasa, I Made Merdana, Anak Agung Ayu Mirah Adi

I Made Bagus Januar Bahari Putra
Undergraduate Student, Faculty of Veterinary Medicine, Universitas Udayana, Bali, Indonesia

Ketut Budiasa
Pharmacology Department, Faculty of Veterinary Medicine, Universitas Udayana, Bali, Indonesia

I Made Merdana
Pharmacology and Pharmacy Department, Faculty of Veterinary Medicine, Universitas Udayana, Denpasar, Bali

Anak Agung Ayu Mirah Adi
Pathology Department, Faculty of Veterinary Medicine, Universitas Udayana, Denpasar, Bali. Email: aaa_mirahadi@unud.ac.id
Online First: December 26, 2020 | Cite this Article
Putra, I., Budiasa, K., Merdana, I., Adi, A. 2020. The effect of Myrmecodia pendans extract toward gastric histology in white rats treated with toxic dose of gentamicin: a preliminary report. Bali Medical Journal 9(3): 924-928. DOI:10.15562/bmj.v9i3.2079


Introduction: Myrmecodia pendans, or traditionally known as ant nest fruit, is one of popular traditional medicines in Indonesia with a wide range of effects such as antidiabetic, anticancer, and free-radical scavenging agents. Despite of the extensive research, reports regarding its toxicity are scarce. Gentamicin is also one of popular and widely used anti-biotic but it is associated with a wide range of toxicity, especially if administered at high dose. Therefore, this study aimed to evaluate the effect of Myrmecodia pendans extract in the mice what received toxic dose of gentamicin.

Method: 24 male white rats were used and randomly divided into 4 groups: P0 (negative control), P1 (100 mg/kgBW intraperitoneal gentamicin), P2 (gentamicyn + 250 mg/kgBW myrmercodia extract), P3 (250 mg/kgBW myrmercodia extract which administered for 7 days and followed by gentamicin). The treatment was given for 10 days and all mice were sacrificed at the end of the study. The stomach was taken from each mouse and examined pathologically using Hematoxylin-Eosin (HE) staining.

Results: The necrosis was found in all groups that received gentamicin (P1-P3) with P2 had the most severe necrosis. Hemorrhage was only found in group that received Myrmecodia extract (P2 and P3) and, again, P2 had higher score of hemorrhage compared to P3.

Conclusion: The administration of Myrmecodia extract at 250 mg/kgBW together with toxic dose of gentamicin exacerbate the gastric tissue damage in Wistar rats.

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