The future of three-dimensional skin graft: a mini-review

Zendio Abednego Santoso

Zendio Abednego Santoso
Faculty of Medicine, Universitas Hang Tuah, Surabaya, Indonesia. Email:
Online First: April 01, 2021 | Cite this Article
Santoso, Z. 2021. The future of three-dimensional skin graft: a mini-review. Bali Medical Journal 10(1): 122-125. DOI:10.15562/bmj.v10i1.2242

Over the last few years, the development of three-dimensional (3D) skin bioprinting has increased rapidly. The concept of bioprinting involves a computer in designing using conventional 3D printing. 3D bioprinting can produce tissue structures such as skin and have the opportunity to substitute autografts, which are still the gold standard today. Network construction in bioprinting requires stages in the network structure design, selection of cell and biomaterial raw materials, and the molding process. The use of keratinocytes and fibroblasts is used as the main raw material in the manufacture of the dermis and epidermis layers. The biomimetic technique will combine these raw materials with other biomaterials (hydrogel, collagen, fibrin, gelatin, alginate, chitosan, and chitin) and growth factors (hydrocortisone, thrombin, and FGF-2) so that the physiological condition of the skin can be created. Currently, 3D bioprinting research continues to develop in response to the various shortcomings and challenges faced. The purpose of this review is to discuss the current use of 3D bioprinting technology, the principles of this technology and the prospects for 3D skin bioprinting in the future.


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