ORIGINAL ARTICLE

Prostate acinar adenocarcinoma: a comparative study of Her-2 and Ki-67 expression on Gleason patterns

Ika Pawitra Miranti, Hermawan Istiadi , Putri Ajeng Ayu Larasati, Indra Wijaya, Dik Puspasari, Vega Karlowee

Ika Pawitra Miranti
Anatomical Pathology Department, Faculty of Medicine, Universitas Diponegoro-Dr. Kariadi Hospital, Semarang, Indonesia

Hermawan Istiadi
Anatomical Pathology Department, Faculty of Medicine, Universitas Diponegoro-Dr. Kariadi Hospital, Semarang, Indonesia. Email: hermawanistiadi@fk.undip.ac.id

Putri Ajeng Ayu Larasati
Anatomical Pathology Department, Faculty of Medicine, Universitas Diponegoro-Dr. Kariadi Hospital, Semarang, Indonesia

Indra Wijaya
Anatomical Pathology Department, Faculty of Medicine, Universitas Diponegoro-Dr. Kariadi Hospital, Semarang, Indonesia

Dik Puspasari
Anatomical Pathology Department, Faculty of Medicine, Universitas Diponegoro-Dr. Kariadi Hospital, Semarang, Indonesia

Vega Karlowee
Anatomical Pathology Department, Faculty of Medicine, Universitas Diponegoro-Dr. Kariadi Hospital, Semarang, Indonesia
Online First: July 31, 2021 | Cite this Article
Miranti, I., Istiadi, H., Larasati, P., Wijaya, I., Puspasari, D., Karlowee, V. 2021. Prostate acinar adenocarcinoma: a comparative study of Her-2 and Ki-67 expression on Gleason patterns. Bali Medical Journal 10(2): 677-682. DOI:10.15562/bmj.v10i2.2251


Background: Prostate cancer is one the most common malignancy in men worldwide, and acinar adenocarcinoma is the most prevalent one. Gleason score and grade group is recently used to predict the therapy and prognosis based on Gleason pattern. Her-2 and Ki-67 are markers that are widely studied in breast cancer, but their role in prostate cancer is still unclear. Her-2 is a transmembrane protein involved in oncogenesis. We hope by using the basic determinant Gleason pattern to analyze the expression of these two markers, it will contribute to understand its carcinogenesis and prognosis. The aim of the study is to determine the expression of Her-2 and Ki-67 in Gleason grade of prostate acinar adenocarcinoma.

Methods: An analytic observational study with cross-sectional design was done using 31 paraffin-embedded tissues of prostate acinar adenocarcinoma from the Anatomic Pathology Laboratory of Dr. Kariadi General Hospital, focusing on 48 areas classified into pattern 3, 4, and 5. Immunohistochemical staining was performed using Her-2 and Ki-67 antibodies to all tissues and the datas were analyzed using the Kruskal Wallis test and the Spearman test.

Results: There are significant differences and correlations between the expression of Ki-67 and Gleason grade, but there are neither significant differences nor correlation between Her-2 expression and Gleason grade.

Conclusion: Her-2 expression is almost the same among Gleason grade as basic determinant of prostate acinar adenocarcinoma

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