Skip to main content Skip to main navigation menu Skip to site footer

Comparison of brain-derived neurotrophic factor (BDNF) serum level in inflammatory and non-inflammatory acne vulgaris

  • Sweet Caroline Marpaung ,
  • Nelva Karmila Jusuf ,
  • Imam Budi Putra ,


Abstract

Background: Acne vulgaris is a chronic and self-limiting inflammation disorder of the pilosebaceous unit, generally manifested in adolescents with polymorphic lesions, such as comedones, papules, nodules, and cyst. Brain-derived neurotrophic factor (BDNF) is a member of neurotrophins that can be downregulated because of stress. It is suspected that a lower BDNF level is induced inflammatory process, although its relationship with acne vulgaris has not been widely studied. This study compared BDNF serum levels in the inflammatory and non-inflammatory type of acne vulgaris.

Methods: This is analytical observational research with a cross-sectional design that involved 31 acne vulgaris patients with inflammatory lesions and 31 acne vulgaris patients with non-inflammatory lesions. Each subject was interviewed and going through dermatology examinations, followed by blood sampling to assessed their BDNF serum levels through the ELISA test. The collected data were analyzed statistically using an independent T-test. P<0.05 was significant.

Result: The mean BDNF serum levels in acne vulgaris patients were 32,53±6,32 ng/ml. In subjects with inflammatory-type lesions, the mean BDNF level is 27,55±3,31 ng/ml. While, in the non-inflammatory type lesions group, the mean BDNF is 37,51±4,37 ng/ml. The BDNF serum level is significantly lower in inflammatory-type subjects than in non-inflammatory type (p < 0,001).

Conclusion: There was a significant difference in serum BDNF levels between the inflammatory and non-inflammatory type acne groups.
Keywords: acne vulgaris brain-derived neurotrophic factor BDNF stress

References

  1. He H, Tian J, Deng Y, Xiong X, Xu Y, Liao Y, et al. Association of Brain-derived Neurotrophic Factor Levels and Depressive Symptoms in Young Adults with Acne Vulgaris. BMC Psychiatry. 2019;19:193.
  2. Wasitaatmadja SM, Arimuko A, Norawati L, Bernadette I and Legiawati L (eds). Pedoman tata laksana akne di Indonesia. 2th edition. Jakarta: Centra communications; 2016.
  3. Tan AU, Schlosser BJ, and Paller AS. A Review of Diagnosis and Treatment of Acne in Adult Female Patients. International Journal of Women's Dermatology. 2018;4:56-71.
  4. Sari L, Jusuf NK, Putra IB. Bacterial Identification of Acne Vulgaris. Bali Medical Journal. 2020; 9(3): 753-6. DOI: 10.15562/BMJ.v9i3.173
  5. Goh C, Cheng C, Agak G, Zanglein AL, Graber EM, Thiboutot DM, and Kim J. Acne vulgaris. In: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, Orringer JS, editors. Fitzpatrick's Dermatology in General Medicine. 9th edition. New York: McGraw Hill Companies; 2019. p.1391-412.
  6. Fatemi F, Najafian J, Nasab SS, and Nilforoushzadeh, MA. Treatment of Acne Vulgaris Using the Combination of Topical Erythromycin and Miconazole. J Skin Stem Cell. 2014;1(3):e23330.
  7. Zaenglein AL. Acne Vulgaris. The New England Journal of Medicine. 2018;379:1343-52.
  8. Jusuf NK, Putra IB, Sari L. Differences of Microbiome Found in Non-Inflammatory and Inflammatory Lessons of Acne Vulgaris. Clin Cosmet Investig Dermatol. 2020;13:773-80. DOI: 10.2147/CCID.S272334
  9. Brigadski T and Lehmann V. BDNF: A Regulator of Learning and Memory Processes with Clinical Potential. E-Neuro forum. 2014;5:1-11.
  10. Vaghi V, Polacchini A, Baj G, Pinheiro VLM, Vicario A, and Tongiorgi E. Pharmacological Profile of Brain-derived Neurotrophic Factor (BDNF) Splice Variant Translation Using a Novel Drug Screening Assay: A Quantitative Code. The Journal of Biological Chemistry. 2014;289(40):27702-27713.
  11. Blur I, Erdogan HK, Ciftci E, Canaz F, Yigitaslan S, Yildiz P, et al. Evaluating the Role of Neurotrophins in Psoriasis and Metabolic Syndrome Relationship. Turk J Dermatol. 2017;11:168-73.
  12. Libman-Sokolowska M, Drozdowicz E, and Nasierowski T. BDNF As A Biomarker in the Course and Treatment of Schizophrenia. Psychiatr Pol. 2015;49(6):1149-1158.
  13. Mikhael NW, Hamed, AM, Mansour AI, and Abdelrahman ES. Serum Levels of Brain-derived Neurotrophic Factor in Patients with Acne Vulgaris. J Cosmet Dermatol. 2019:1-9.
  14. Lynn DD, Umari T, Dunnick CA, and Dellavalle RP. The epidemiology of acne vulgaris in late adolescence. Adolescent Health. Medicine and Therapeutics. 2016; 7: 13-25.
  15. Snast I, Dalal A, Twig G, Astman N, Kedem R, Levin D, et al. acne and obesity: A nationwide study of 600,404 adolescents. Journal American Academy of Dermatology. 2019:1-6. DOI : 10.1016/j.jaad.2019.04.009
  16. Alshammari SA, Alamri Y, Alanazi AM, Almuhanna SA, Punjabi L, and Alsnaidi NA. Prevalence and associated risk factors of acne relapse among Saudi acne vulgaris patients using isotretinoin. Saudi Pharmaceutical Journal. 2020;28: 374 – 9. DOI : 10.1016/j.jsps.2020.01.019
  17. Liang J, Deng G, and Huang He. The activation of BDNF reduced inflammation in the spinal cord injury model by TrkB/p38 MAPK signaling. Experimental and Therapeutic Medicine. 2019;1688-96. DOI: 10.3892/etm.2018.7109
  18. Erpolat S, Celik HT, and Bozkurt B. Brain-derived Neurotrophic Factor are Increased in Serum Levels of Patients with Symptomatic Dermographism. Advances in Dermatology and Allergology 2017;34(4):346-349.
  19. Jiang Y, Wei N, Zhu J, Lu T, Chen Z, Xu G, and Liu X. Effects of Brain-derived Neurotrophic Factor on Local Inflammation in Experimental Stroke of Rat. Mediators of Inflamm. 2010:1-10. DOI: 10.1155/2010/372423.
  20. Chaldakov GN, Tonchev AB, and Aloe L. NGF and BDNF: From Nerves to Adipose Tissue, from Neurokines to Metabokines. Rivista di Psichiatria. 2009;44(2):79-87.
  21. Ganceviciene R, et al. Involvement of the Corticotropin-Releasing Hormone System in the Pathogenesis of Acne Vulgaris. Br J Dermatol. 2009;160(2):345-52. DOI: 10.1111/j.1365-2133.2008.08959.x
  22. Jusuf NK, Putra IB, Sutrisno AR. Correlation Between Stress Scale and Serum Substance P Level in Acne Vulgaris. Int J Gen Med. 2021;1(14):681-6. DOI: 10.2147/IJGM.S294509
  23. Sutrisno AR, Jusuf NK, and Putra IB. Correlation between Stress Scale and Severity of Acne Vulgaris. Bali Medical Journal. 2020;9:376-9. DOI: 10.15562/BMJ.v9i1.1749

How to Cite

Marpaung, S. C., Jusuf, N. K., & Putra, I. B. (2021). Comparison of brain-derived neurotrophic factor (BDNF) serum level in inflammatory and non-inflammatory acne vulgaris. Bali Medical Journal, 10(2), 659–662. https://doi.org/10.15562/bmj.v10i2.2438
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX

HTML
1

Total
0

Share

Search Panel

Sweet Caroline Marpaung
Google Scholar
Pubmed
BMJ Journal

Nelva Karmila Jusuf
Google Scholar
Pubmed
BMJ Journal

Imam Budi Putra
Google Scholar
Pubmed
BMJ Journal