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Adipose-Derived Stem Cells (ADSCs): a review article


Introduction: Stem Cells (SC) are cells having characteristic features of self-renewal and plasticity that can differentiate and proliferate into many types of cells to form an individual. This literature study aims to evaluate the Adipose-Derived Stem Cells (ADSCs) comprehensively.

Methods: A comprehensive literature search was conducted by the author to obtain relevant studies from PubMed, MEDLINE, Embase, PreMEDLINE, Embase, PsycINFO, Scopus, and Cochrane for the last fifteen years. The author sought articles with the following keywords: Adipose-Derived Stem Cells, AND Fibrosis, OR Wound Healing, OR Growth Factor, hypoxic culture OR, Normoxic Culture, OR cytokine.

Results:  ADSCs become one of the strong potential stem cell-based therapies, for instance, preventing fibrosis tissue formation in the wound healing process. The source is mainly on the body’s surface, and harvesting using a minimally invasive procedure made ADSCs superior to the other stem cell sources. Using a better precondition technique, such as the hypoxia precondition technique, can increase the proliferation of stem cells and the viability of stem cells.

Conclusion: ADSCs are a source of visible cell-based therapy to be currently used. ADSCs can counteract fibrosis by the anti-inflammatory and anti fibrosis effects.


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How to Cite

Pramana, I. B. P., Oka, A. A. G., Astawa, I. N. M., & Mahadewa, T. G. B. (2021). Adipose-Derived Stem Cells (ADSCs): a review article. Bali Medical Journal, 10(3), 881–886.




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Ida Bagus Putra Pramana
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Anak Agung Gde Oka
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I Nyoman Mantik Astawa
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Tjokorda Gde Bagus Mahadewa
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