ORIGINAL ARTICLE

Influence of Artificial Tear Related with Conjunctival Goblet Cell Density in Glaucoma Patients with Latanoprost Therapy

Anak Agung Mas Putrawati , Ni Made Oka Handayani, Ni Ketut Niti Susila, Putu Budhiastra, I Gede Raka Widiana, Anak Agung Ayu Sukartini Djelantik

Anak Agung Mas Putrawati
Ophthalmology Department, Faculty of Medicine Udayana University/Sanglah Hospital Denpasar Bali Indonesia. Email: masputra@yahoo.com

Ni Made Oka Handayani
Ophthalmology Department, Faculty of Medicine Udayana University/Sanglah Hospital Denpasar Bali Indonesia

Ni Ketut Niti Susila
Ophthalmology Department, Faculty of Medicine Udayana University/Sanglah Hospital Denpasar Bali Indonesia

Putu Budhiastra
Ophthalmology Department, Faculty of Medicine Udayana University/Sanglah Hospital Denpasar Bali Indonesia

I Gede Raka Widiana
Division of Nephrology and Hypertension Department of Internal Medicine Udayana University Sanglah General Hospital, Bali

Anak Agung Ayu Sukartini Djelantik
Ophthalmology Department, Faculty of Medicine Udayana University/Sanglah Hospital Denpasar Bali Indonesia
Online First: September 06, 2016 | Cite this Article
Putrawati, A., Handayani, N., Susila, N., Budhiastra, P., Widiana, I., Sukartini Djelantik, A. 2016. Influence of Artificial Tear Related with Conjunctival Goblet Cell Density in Glaucoma Patients with Latanoprost Therapy. Bali Medical Journal 5(1): 141-146. DOI:10.15562/bmj.v5i1.286


Purpose: To know influence of artificial tear related with conjunctival goblet cell density in glaucoma patient with latanoprost therapy. Method: Pre-posttest design with expanded randomized study. This study was performed at Eye Policlinic Sanglah Public Hospital Denpasar and Bali Mandara Hospital from October until December 2015. Forty eyes were taken for impression cytology specimen to search goblet cell density before and 30 days after therapy. Mean difference of goblet cell changes before and after therapy between case and control analyzed with independent t-test. Results: There were enhancements of conjunctival goblet cell mean density on group with artificial tear before and after therapy 83 + 97 cell/mm2 to 92 + 88 cell/mm2. There was reduction of conjunctival goblet cell mean density of group without artificial tear from 144 + 169 cell/mm2 to 78 + 103 cell/mm2.Mean difference between both group in this study differ not significant statistically (p=0,178). However, mean difference of conjunctival goblet cell density before and after therapy between both groups differ -75+ 54 cell/mm2. Conclusions: Artificial tears have a considerable effect (important), although not statistically significantly.

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