Skip to main content Skip to main navigation menu Skip to site footer

Relationship between serum IgE levels and psoriasis area and severity index (PASI) score in psoriasis vulgaris

Abstract

Introduction: Psoriasis is an immune system-mediated inflammatory disorder characterized by skin inflammation, epidermal hyperplasia, and other comorbidities. Based on medical data from H. Adam Malik hospital in 2011, the proportion of psoriasis vulgaris incidence was 0.81%. It is important to assess the severity of the disease. The most frequently used measuring instrument is the Psoriasis Area and Severity Index (PASI) score. Elevated serum IgE levels have been reported in some cases of psoriasis. The relationship between serum IgE levels and psoriasis severity is controversial. The study aimed to determine the relationship between serum IgE levels and PASI scores in psoriasis vulgaris.

Method: An observational analytic study with a cross-sectional approach to 37 subjects of psoriasis vulgaris at Haji Adam Malik General Hospital Medan. Patients who meet the criteria are recorded with basic data in personal identity, history taking, physical examination, and dermatological examination. Furthermore, the calculation of the Psoriasis Area and Severity Index (PASI) score and serum IgE levels using ARCHITECT CI8200 with Quantia IgE reagent. The data will be analyzed using SPSS.

Results: Psoriasis vulgaris mostly occurs in women (54.1%) with the most age group 31-45 years (40.5%). The median age was 35 years with a range of 21-67 years. The proportion of study subjects with high serum IgE levels (?100) was 26 people (70.3%) with a median of 130 IU/ml and a range of 25-475.5 IU/ml. Based on the PASI score, the highest proportion were subjects with moderate and mild PASI scores as many as 21 people (56.8%) and 13 people (35.1%). The median PASI score was 6, with a range of 0.5 – 10.40. The results of the Pearson correlation test (p) serum IgE levels and PASI scores obtained p-value = 0.0001, which indicated that the relationship between serum IgE levels and PASI scores was significant. The value of the correlation coefficient (r) of 0.909 indicates that the direction of the positive correlation with the strength of the correlation is very strong.

Conclusion: There is a relationship between serum IgE levels and Psoriasis Area and Severity Index (PASI) scores in psoriasis vulgaris.

 

References

  1. Amstrong AW, Read C. Pathophysiology, clinical presentation, and treatment of psoriasis. JAMA Clin Rev Edu. 2020; 323(19): 1945-1960.
  2. Chen C, Zheng X, Yang P, Zheng Y. High serum IgE concentration in patients with psoriasis. Clin Res Dermatol Open Access. 2017; 4(4): 1-4.
  3. Lotfi RA, El-Sayed MH, El-Gabry SH. Assessment of serum levels of IgE in psoriasis: the relationship with clinical types of the disease. J Egypt Women Dermatolog Soc. 2015; 12: 62-67.
  4. Khalaf HY, Hussein TA, Fadheel BM. The study of serum complement C3, C4 and immunoglobulin E (IgE) in psoriasis patients. Baghdad Sci J. 2015; 12(4): 708-15.
  5. Lajevardi V, Ghiasi M, Goodarzi A, Mohtasham S, Ansari M, Hedayat K, et al. Total serum IgE concentration in patients with psoriasis. Acta Medica Iranica. 2014; 52(7): 515-18.
  6. Levinson W, Chin-Hong P, Joyce EA, Nussbaum J, Schwartz B. Review of Medical Microbiology and Immunology: A Guide to Clinical Infectious Diseases. 15th ed. McGraw Hill Education, 2018.
  7. Yan et al. Is there a pathogenic role for IgE in psoriasis?. Brit J Dermatol. 2016; 175: 2-22.
  8. Murphy K, Weaver C. Janeway’s Immunobiology. 9th ed. New York: Taylor & Francis Group, 2017.
  9. Hugh JM, Weinberg JM. Update on the pathophysiology of psoriasis. Cutis. 2018; Suppl: 102(5): 6-12.
  10. Ljosaa TM, Stubhaug A, Mork C, Moum T, Wahl AK. Improvement in psoriasis area and severity index score predicts improvement in skin pain over time in patients with psoriasis. Acta Derm Venereol. 2012; 92.
  11. Otero ME, Geel MJ, Hendriks JC, Kerkhof PC, Syger MM, Jong EM. A pilot study on the psoriasis area and severity index (PASI) for small areas: presentasion and implications of the low PASI score. J Dermatolog Treat. 2014; 1-4.
  12. Timotijevic ZS, Majcan P, Trajkovic G, Relic M, Novakovic T, Mirkovic M, et al. The impact of changes in psoriasis area and severity index by body region on quality of life in patients with psoriasis. Acta Dermatovenerol Croat. 2017; 25(3): 215-222.
  13. Seminara NM, Abuabara K, Shin DB, Langan SM, Kimmel SE, Margolis D, Troxel AB, et al. Validity of The Health Improvement Network (THIN) for the study of psoriasis. Br J Dermatol. 2011; 164: 602–609.
  14. Cantika AS. Hubungan Derajat Keparahan Psoriasis Vulgaris Terhadap Kualitas Hidup Penderita. Jurnal Media Medika Muda. 2012; 3-10.
  15. Astrid C, Putranti IO, Purwanti KD. Perbedaan Tingkat Keparahan Psoriasis Pada Pasien Psoriasis Dengan dan Tanpa Fokal Infeksi. Mandala of Health : Scientific Journal. 2018; 11(2): 79-93.
  16. Lufiana F, Siregar Y, Yosi A. Kadar Vitamin D dalam Plasma Darah Pada Pasien Psoriasis di Kota Medan. Jurnal Keperawatan dan Fisioterapi. 2019; 2(1) :6-11.
  17. Coevic R, Mance M, Mokos ZB, Svetec M, Kostovic K, Buzina DS. Psoriasis: Female Skin Changes in Various Hormonal Stages Throughout Life - Puberty, Pregnancy and Menopause. BioMed Research International. 2013; 2013: 1-6.
  18. Gelfand JM, Weinstein R, Porter SB, Neimann AL, Berlin JA, Margolis DJ. Prevalence and Treatment of Psoriasis in the United Kingdom : A Population-Based Study. Arch Dermatol. 2005;141:1537-1541.
  19. Michalek IM, Loring B, John SM. A systematic review of world wide epidemiology of psoriasis. JDEAV. 2017; 31: 205-212.
  20. Affandi AM, Khan I, Saaya NN. Epidemiology and clinical features of adult patients with psoriasis in Malaysia: 10-year review from the Malaysian Psoriasis registry (2007-2016). Dermatolog Res and Pract. 2018; 1-8.
  21. Valenzuela F, Silva P, Valdes MP, Papp K. Epidemiology and Quality of Life of Patients with Psoriasis in Chile. Actas Dermosifiliogr. 2011; 102(10): 810-816.
  22. Trettel A, Spehr C, Korber A, Augustin M. The Impact of Age on Psoriasis Health Care in Germany. Journal of The European Academy of Dermatology and Venereology. 2017; 31(5): 870-875.
  23. Halilovic EK. Total Serum Immunoglobulin E Levels in Patients with Psoriasis. Mater Sociomed. 2020; 32(2): 105-107.
  24. Waworuntu G, Tanjung C, Roesyanto-Mahadi ID. Profil kadar vascular endothelial growth factor (VEGF) serum berdasarkan karakteristik pasien psoriasis vulgaris di RSUP H. Adam Malik Medan. MDVI. 2017; 44(44): 8-14.
  25. Abdelmoaty A, Elkheshen G. Total Serum IgE in Patients with Psoriasis Vulgaris and Its Relation to The Severity of The Disease. Al-Azhar Assiut Medical Journal. 2014; 12(4).
  26. Kurtovic NO, Halilovic EK. Serum Levels of Total Immunoglobulin E in Patients with Psoriasis : Relationship of Clinical Type of Disease. Med ARH. 2010; 64(1): 28-29.
  27. Weigl BA. The Significance of Stress Hormones (Glucocorticoids, Cathecolamines) for Eruptions and Spontaneous Remission Phases in Psoriasis. International Journal of Dermatology. 2000; 39: 678-688.
  28. Wardhana M. Stres Psikologis pada Pasien Psoriasis : Suatu Kajian Psikoneuroimunologi. MDVI. 2012; 39(1): 10-14.
  29. Kim J, Bissonnette R, Lee J, Rosa JC, Farinas MS, Lowes MA, et al. The Spectrum of Mild to Severe Psoriasis Vulgaris is Defined by a Common Activation of IL-17 Pathway Genes, but with Key Differences in Immune Regulatory Genes. Journal of Investigative Dermatolog. 2016; 136: 2173- 2182.
  30. Budiastuti A. Korelasi Kadar TNF-? dan skor Psoriasis Area and Severity Index (PASI) Pada Pasien Psoriasis. Media Medika Indonesiana. 2011; 45(2): 133-137.
  31. Budini SS, Cholis M, Rofiq A. Kadar TNF-? Lesi Kulit dengan Derajat Keparahan Psoriasis Vulgaris. Berkala Ilmu Kesehatan Kulit & Kelamin. 2014; 26(1): 22-28.
  32. Puruhito B. Korelasi antara Kadar IFN-? Serum dengan Skor PASI pada Psoriasis. Media Medika Muda. 2017; 2(1): 63-68.
  33. Putri DU. Hubungan Skala Stres dan Kadar Kortisol Serum dengan skor Psoriasis Area and Severity Index (PASI) pada Pasien Psoriasis Vulgaris. Repository USU. 2018.
  34. Robati RM, Toossi P, Roodsari MR, Khalilazar S, Abolhasani E, Namazi N, et al. Association of Psoriasis Severity with Serum Prolactin, Thyroid Hormones and Cortisol Before and After Treatment. The Scientific World Journal. 2013; 2013: 1-5.
  35. Safitri WR. Analisis Korelasi Pearson dalam Menentukan Hubungan Antara Kejadian Demam Berdarah Dengue dengan Kepadatan Penduduk di Kota Surabaya pada Tahun 2012-2014. Journal STIKES Pemkab Jombang. 2014. 1-9.
  36. Przybilla B, Ring J, Volk M. Total serum IgE levels in dermatologic diseases. Hautarzt. 1986; 37(2):77-82.

How to Cite

Hidayat, F. A., Nababan, K. A., & Roesyanto, I. D. (2021). Relationship between serum IgE levels and psoriasis area and severity index (PASI) score in psoriasis vulgaris. Bali Medical Journal, 10(3), 1020–1025. https://doi.org/10.15562/bmj.v10i3.2861

HTML
0

Total
0

Share

Search Panel

Fitra Aina Hidayat
Google Scholar
Pubmed
BMJ Journal


Kristo Alberto Nababan
Google Scholar
Pubmed
BMJ Journal


Irma Damayanti Roesyanto
Google Scholar
Pubmed
BMJ Journal