ORIGINAL ARTICLE

Association of SDF-1 with Metastasis in Breast Cancer Patient at Sanglah Hospital, Bali

Kristanto Yuli Yarso , Suyatmi Suyatmi, Faris Khairuddin Syah, Ida Bagus Tjakra Wibawa Manuaba, Hakimi Hakimi, Indwiani Astuti, Teguh Aryandono

Kristanto Yuli Yarso
Department of Surgery, Oncology Division Medical Faculty of Sebelas Maret University Solo-Indonesia Department of Surgery, Division of Oncologic Surgery, Faculty of Medicine Udayana University Bali-Indonesia. Email: yarsaonko@gmail.com

Suyatmi Suyatmi
Medical Faculty of Sebelas Maret University Solo-Indonesia

Faris Khairuddin Syah
Medical Faculty of Sebelas Maret University Solo-Indonesia

Ida Bagus Tjakra Wibawa Manuaba
Department of Surgery, Division of Oncologic Surgery, Faculty of Medicine Udayana University Bali-Indonesia

Hakimi Hakimi
Department of obstetry Gynecology, Faculty of Medicine Gadjah Mada University Jogjakarta- Indonesia

Indwiani Astuti
Department of Histology, Faculty of Medicine Gadjah Mada University Jogjakarta- Indonesia

Teguh Aryandono
Department of Surgery, Division of Oncologic Surgery, Faculty of Medicine Gadjah Mada University Jogjakarta- Indonesia
Online First: October 17, 2016 | Cite this Article
Yarso, K., Suyatmi, S., Khairuddin Syah, F., Wibawa Manuaba, I., Hakimi, H., Astuti, I., Aryandono, T. 2016. Association of SDF-1 with Metastasis in Breast Cancer Patient at Sanglah Hospital, Bali. Bali Medical Journal 5(3): 484-487. DOI:10.15562/bmj.v5i3.320


Objectives: More than 24% breast cancer patients came to Sanglah Teaching Hospital with distant metastasis which cause 90% of cancer related death. Distant metastasis is complex process of interaction between tumor cells and its micro environment involving a chemoattractant cytokines which lead circulating tumor cells toward target organs. One of the most common cytokines involved in metastasis of multiple tumor is SDF-1, produces by target organ or tumor cells itselves. However, only few stucy ever evaluate the relationship between its concentrations in tumor tissue with metastasis. Method: A cross sectional analysis study was conducted involving clinical data and paraffin blocks from 46 patients. Samples were grouped into metastasis and non-metastasis group and level of tumor tissue SDF-1 was evaluated by immunohistochemistry method. Numerical conversion was done using modified “Mirisola” technique and statistical analysis was conducted using SPSS 16 software. Results: The overall median expression of SDF-1 was 4.83 in which the median is 4.08±2.25 in non-metastatic group and 5.71±2.61 in metastatic group (p=0.012). In addition, parenchymal carcinoma cell had significantly higher expression of SDF-1 compared with microenvironmental cell both in metastatic group (carcinoma cell vs microenvironment; 4,57+1,91 vs 3,68 +2,06; p=0,004) and non-metastatic group (3,19 +2,29 vs 2,16+1,11; p=0.011). Finally, logistic regression analysis of SDF-1 expression also gave significant result that MBC had significantly higher expression of SDF-1 (p=0.039).  Conclusions: There was significant association between of SDF-1 expression and distant metastasis in breast cancer and majority of SDF was produced by cancer cells
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