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Clinical and radiological profiles of metastatic brain tumor in Indonesia: A study at Dr. Soetomo Hospital, Surabaya

  • Nur Akbaryan Anandito ,
  • Djohan Ardiansyah ,

Abstract

Background: Brain metastases have increased over time, and imaging has been considered an important diagnostic tool. In Indonesia, the record of metastatic brain tumors is limited. Therefore, understanding the epidemiology and the imaging characteristics of brain metastases will provide insights into a better diagnosis, management, and therapy towards the disease. This study aimed to evaluate the characteristics of patients with metastatic brain tumors.

Methods: A cross-sectional study was conducted in Neurology Unit at Dr. Soetomo Hospital in Surabaya, Indonesia from August 2018 - July 2019. Patients with metastatic brain tumors were enrolled in the study. Data demographics, clinical, and brain imaging characteristics were collected from the patients’ Brain Tumor Registry. Computerized tomography (CT) scan and magnetic resonance imaging (MRI) was used to assess the images of the brain metastases. Mini-Mental State Exam (MMSE) was used to assess the patient's cognitive function.

Results: Of the total 22 subjects, 14 (63.6%) were male, 13 (59.1%) aged ≥50 years. Headache was the most common clinical symptom, reported by 78.2% of patients. Most of the patients (63.3%) had MMSE score of ≤ 23. CT-scan and MRI imaging suggested that multiple lesions were the most common, 57.8% and 71.4%, respectively. The brain tumor's most frequent was in the parietal and temporal lobes (CT-scan imaging) and temporal and cerebellar lobes based on MRI. Lung tumors were the most common source of brain metastases (50%), followed by breast and nasopharynx cancers (13.6% each); 9% had unknown sources.

Conclusions: Our study suggests that the frequency of metastatic brain tumors is gender and age-specific. Headache with early stage of dementia is common among patients with metastatic brain tumor. Multiple lesions in parietal and temporal lobes with lung cancer as the source are common.

References

  1. Achrol AS, Rennert RC, Anders C, Soffietti R, Ahluwalia MS, Nayak L, et al. Brain metastases. Nat Rev Dis Prim. 2019;5(1). Available from: http://dx.doi.org/10.1038/s41572-018-0055-y
  2. Soffietti R, Cornu P, Delattre JY, Grant R, Graus F, Grisold W, et al. EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force. Eur J Neurol. 2006;13(7):674–81. Available from: http://dx.doi.org/10.1111/j.1468-1331.2006.01506.x
  3. Enrique G-V, Irving S-R, Ricardo B-I, Jesus F-L, Alan R-M, Inigo VAA, et al. Diagnosis and management of brain metastases: an updated review from a radiation oncology perspective. J Cancer Metastasis Treat. 2019;2019. Available from: http://dx.doi.org/10.20517/2394-4722.2019.20
  4. Owonikoko TK, Arbiser J, Zelnak A, Shu H-KG, Shim H, Robin AM, et al. Current approaches to the treatment of metastatic brain tumours. Nat Rev Clin Oncol. 2014/02/25. 2014;11(4):203–22. Available from: https://pubmed.ncbi.nlm.nih.gov/24569448
  5. Dewi M, Loho E, Tubagus VN. Ct-Scan Overview of Intracranial Neoplasms in the Department of Radiology / SMF Fk Unsrat RSup Prof. Dr. R. D. Kandou Manado Period October 2014 - September 2015. e-CliniC. 2016;4(1). Available from: http://dx.doi.org/10.35790/ecl.4.1.2016.10950
  6. Fink KR, Fink JR. Imaging of brain metastases. Surg Neurol Int. 2013;4(Suppl 4):S209–19. Available from: https://pubmed.ncbi.nlm.nih.gov/23717792
  7. Cockrell JR, Folstein MF. Mini-Mental State Examination [Internet]. Principles and Practice of Geriatric Psychiatry. John Wiley & Sons, Ltd; p. 140–1. Available from: http://dx.doi.org/10.1002/0470846410.ch27(ii)
  8. Tabouret E, Metellus P, Gonçalves A, Esterni B, Charaffe-Jauffret E, Viens P, et al. Assessment of prognostic scores in brain metastases from breast cancer. Neuro Oncol. 2013/12/04. 2014;16(3):421–8. Available from: https://pubmed.ncbi.nlm.nih.gov/24311640
  9. Ostrom QT, Wright CH, Barnholtz-Sloan JS. Brain metastases: epidemiology [Internet]. Handbook of Clinical Neurology. Elsevier; 2018. p. 27–42. Available from: http://dx.doi.org/10.1016/b978-0-12-811161-1.00002-5
  10. Sembiring IG. Characteristics of Patients with Metastatic Brain Tumors at H. Adam Malik Hospital in 2014-2016. 2017.
  11. Benna M, Mejri N, Mabrouk M, El Benna H, Labidi S, Daoud N, et al. Brain metastases epidemiology in a Tunisian population: trends and outcome. CNS Oncol. 2018;7(1):35–9. Available from: https://pubmed.ncbi.nlm.nih.gov/29347839
  12. Ruano-Raviña A, Provencio M, Calvo de Juan V, Carcereny E, Moran T, Rodriguez-Abreu D, et al. Lung cancer symptoms at diagnosis: results of a nationwide registry study. ESMO open. 2020;5(6):e001021–e001021. Available from: https://pubmed.ncbi.nlm.nih.gov/33214227
  13. Barnholtz-Sloan JS, Sloan AE, Davis FG, Vigneau FD, Lai P, Sawaya RE. Incidence Proportions of Brain Metastases in Patients Diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol. 2004;22(14):2865–72. Available from: http://dx.doi.org/10.1200/jco.2004.12.149
  14. Ghosh S, Rao PB. Brain Metastases from Solid Tumors: an Institutional Study from South India. Asian Pacific J Cancer Prev. 2015;16(13):5401–6. Available from: http://dx.doi.org/10.7314/apjcp.2015.16.13.5401
  15. Yang B, Lee H, Um S-W, Kim K, Zo J Il, Shim YM, et al. Incidence of brain metastasis in lung adenocarcinoma at initial diagnosis on the basis of stage and genetic alterations. Lung Cancer. 2019;129:28–34. Available from: http://dx.doi.org/10.1016/j.lungcan.2018.12.027
  16. Pope WB. Brain metastases: neuroimaging. Handb Clin Neurol. 2018;149:89–112. Available from: https://pubmed.ncbi.nlm.nih.gov/29307364
  17. Linnert M, Iversen HK, Gehl J. Multiple brain metastases - current management and perspectives for treatment with electrochemotherapy. Radiol Oncol. 2012;46(4):271–8. Available from: https://pubmed.ncbi.nlm.nih.gov/23412694
  18. Schellinger PD, Meinck HM, Thron A. No Title. J Neurooncol. 1999;44(3):275–81. Available from: http://dx.doi.org/10.1023/a:1006308808769

How to Cite

Anandito, N. A., & Ardiansyah, D. (2022). Clinical and radiological profiles of metastatic brain tumor in Indonesia: A study at Dr. Soetomo Hospital, Surabaya. Bali Medical Journal, 11(1), 241–245. https://doi.org/10.15562/bmj.v11i1.3222

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Nur Akbaryan Anandito
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Djohan Ardiansyah
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