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Change in ratio levels of KIM-1 / urine creatinine and increase serum creatinine levels in human immunodeficiency virus (HIV) patients receiving tenofovir-based antiretroviral (ARV) combination therapy

  • I Dewa Gede Teguh Krisna Murti ,
  • I Gde Raka Widiana ,

Abstract

Background: Human immunodeficiency virus (HIV)-associated nephropathy refers to developing kidney disease associated with HIV infection. Tenofovir is associated with an increased risk of acute kidney injury (AKI). Kidney injury molecule-1 (KIM-1) in urine is very specific for kidney injury. This study aimed to determine the changes in the ratio between the levels of KIM-1/urine creatinine and the increase in serum creatinine levels with the incidence of decreased kidney function in people with HIV.

Method: This was an observational-analytic study. Subjects were taken using consecutive sampling at Sanglah Hospital Denpasar in 2018. KIM-1 levels were measured by the ELISA method.

Results: This study involved 35 patients (21 males and 14 females) with a mean age of 34.89 ± 10.05 years old. The average levels of KIM-1/urine creatinine at 0 hours was 11.039 ± 12.175 ng/ml), KIM-1/urine creatinine at 12  was 12.382 ± 14.671 ng/ml), KIM-1/urine creatinine at 72 was 10.272 ± 11.843 ng/ml). There were no statistically significant differences in the ratio of hours 0 to 12 hours (p = 0.295), and between hours 0-72 (p = 0.413). But there was a significant difference in creatinine levels for 3 months with the initial mean serum (0.848 ± 0.201) and 3 months of evaluation (1.002 ± 0.198) (p = <0.001).

Conclusion: There was no difference in the ratio of changes in serum KIM-1/creatinine levels during the evaluation of 0, 12, and 72 hours. However, there was an increase in serum creatinine levels between the beginning and 3 months of evaluation.

References

  1. Joint United Nations Programme on HIV/AIDS (UNAIDS). AIDS by the Numbers. Joint United Nations Programme on HIV/AIDS (UNAIDS). 2016. Geneva, Switzerland. Available at: http:// www.unaids.org/ sites/default/files/ media_asset/ AIDS-by-the numbers2016en . pdf
  2. Maartens G, Celum C, Lewin SR. HIV infection: epidemiology, pathogenesis, treatment, and prevention. Lancet. 2014;384:258-327.
  3. Szczech LA, Hoover DR, Feldman JG, Cohen MH, Gange SJ, Gooze L, et al. Association between renal disease and outcomes among HIV-infected women receiving or not receiving antiretroviral therapy. Clinical Infectious Diseases. 2004;39(8):1199–1206.
  4. Rosenberg AZ, Naicker S, Winkler CA, Koop JB. HIV-associated nephropathies: epidemiology, pathology, mechanisms and treatment. Nat Rev Nephrol. 2015;11:150–160.
  5. Izzedine H, Hulot JS, Vittecoq D, Gallant JE, Staszewski S, Launay-Vacher V, et al. Study 903 Team. Long-term renal safety of tenofovir disoproxil fumarate in antiretroviral-naive HIV-1-infected patients. Data from a double-blind randomized active controlled multicentre study. Nephrol Dial Transplant. 2005;20(4):743–746.
  6. Nishijima T, Komatsu H, Gatanaga H, Aoki T, Watanabe K, Kinai E, et al. Impact of small body weight on tenofovir-associated renal dysfunction in HIV-infected patients: A retrospective cohort study of Japanese patients. PLoS ONE. 2011;6:e22661.
  7. Jotwani V, Scherzer R, Estrella MM, Jacobson LP, Witt MD, Palella Jr FJ, et al. HIV infection, tenofovir, and urine α1-microglobulin: a cross-sectional analysis in the multicenter AIDS Cohort Study. Am J Kidney Dis. 2016;68(4):571-581.
  8. Peralta CA, Katz R, Bonventre JV, Sabbisetti V, Siscovick D, Sarnak M, et al. Associations of urinary levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) with kidney function decline in the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis. 2012;60(6):904-911.
  9. Vaidya VS, Waikar SS, Ferguson MA, Collings FB, Sunderland K, Gioules C, et al. Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans. Clin Transl Sci. 2008;1(3):200-208.
  10. Boswell MT, Rossouw TM. Approach to acute kidney injury in HIV-infected patients in South Africa. S Afr J HIV Med. 2017;18(1):a714.
  11. Muiru AN, Shlipak MG, Scherzer R, Zhang WR, Ascher SB, Jotwani V, et al. Kidney disease risk factors associate with urine biomarkers concentrations in HIV-positive persons; a cross-sectional study. BMC Nephrol. 2019;20(1):4.
  12. Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, et al. Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012;92(4):414-417.
  13. Ezinga M, Wetzels JF, Bosch ME, van der Ven AJ, Burger DM. Long-term treatment with tenofovir: prevalence of kidney tubular dysfunction and its association with tenofovir plasma concentration. Antivir Ther. 2014;19(8):765-771.
  14. Ray AS, Cihlar T, Robinson KL, Tong L, Vela JE, Fuller MD, et al. Mechanism of active renal tubular efflux of tenofovir. Antimicrob Agents Chemother. 2006;50(10):3297-3304.
  15. Rodriguez-Nóvoa S, Alvarez E, Labarga P, Soriano V. Renal toxicity associated with tenofovir use. Expert Opin Drug Saf. 2010;9(4):545-559.
  16. Khreba NA, Abdelsalam M, Wahab AM, Sanad M, Elhelaly R, Adel M, et al. Kidney injury molecule 1 (KIM-1) as an early predictor for acute kidney injury in post-cardiopulmonary bypass (CPB) in open heart surgery patients. Int J Nephrol. 2019;2019:6265307.
  17. Koyner JL, Vaidya VS, Bennett MR, Ma Q, Worcester E, Akhter SA, et al. Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury. Clin J Am Soc Nephrol. 2010;5(12):2154–2165.
  18. Han WK, Wagener G, Zhu Y, Wang S, Lee HT. Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery. Clin J Am Soc Nephrol. 2009;4(5):873-882.
  19. Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV. Kidney injury molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int. 2002;62(1):237-244.
  20. van Timmeren MM, van den Heuvel MC, Bailly V, Bakker SJ, van Goor H, Stegeman CA. Tubular kidney injury molecule-1 (KIM-1) in human renal disease. J Pathol. 2007 Jun;212(2):209-217.
  21. Han WK, Alinani A, Wu CL, Michaelson D, Loda M, McGovern FJ, Thadhani R, Bonventre JV. Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma. J Am Soc Nephrol. 2005;16(4):1126-1134.
  22. Yazie TS, Orjino TA, Degu WA. Reduced kidney function in tenofovir disoprocil fumarate based regimen and associated factors: a hospital based prospective observatiobal study in Ethiopian patients. International Journal of Nephrology. 2019;2019:9172607.
  23. Bickel M, Khaykin P, Stephan C, Schmidt K, Buettner M, Amann K, et al. Acute kidney injury caused by tenofovir disoproxil fumarate and diclofenac co-administration. HIV Med. 2013;14(10):633-638.

How to Cite

Murti, I. D. G. T. K., & Widiana, I. G. R. (2022). Change in ratio levels of KIM-1 / urine creatinine and increase serum creatinine levels in human immunodeficiency virus (HIV) patients receiving tenofovir-based antiretroviral (ARV) combination therapy. Bali Medical Journal, 11(1), 503–507. https://doi.org/10.15562/bmj.v11i1.3249

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I Dewa Gede Teguh Krisna Murti
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BMJ Journal


I Gde Raka Widiana
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BMJ Journal