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TNF-α serum level between SARS-CoV-2 infected pregnant women with normal pregnant women in Dr. Soetomo General Hospital Surabaya

  • Margaretha Claudhya Febryanna ,
  • Manggala Pasca Wardhana ,
  • Muhammad Ilham Aldika Akbar ,
  • Arif Rahman Nurdianto ,


Background: Pregnant women infected with SARS-CoV-2 experienced increased pro-inflammatory cytokines, including TNF-α, resulting in a cytokine storm condition. This study aimed to compare TNF-α levels between pregnant women infected and not infected with COVID-19 in the third trimester.

Method: This observational research was conducted with cross sectional design. Our study included pregnant women who came to the delivery room/inpatient at Dr. Soetomo General Hospital Surabaya before or during labor between May and June 2021. The inclusion criteria were third trimester gestational age or >28 weeks with SARS-RT-PCR nasopharyngeal swab result. The exclusion criteria were all significant pregnancy complications. The pregnant woman coming to the delivery room will be screened for COVID-19, and blood samples will be examined using the flow cytometry method for the cytokine Th1: TNF-α.

Result: There were no significant differences in TNF-α levels in pregnant women who were infected and not infected with COVID-19 (median 3.42 (7.24) pg/ml vs. 2.70 (3.06) pg/ml. p=0.138). There was also no significant difference in TNF-α levels in pregnant women with symptomatic vs. asymptomatic COVID-19 infection (3.21(3.97) vs. 2.41(2.71) pg/ml; p=0.314).

Conclusion: This study revealed no significant difference in TNF-α serum level between SARS-CoV-2 infected pregnant women with normal pregnant women.


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How to Cite

Febryanna, M. C. ., Wardhana, M. P., Akbar, M. I. A. ., & Nurdianto, A. R. (2022). TNF-α serum level between SARS-CoV-2 infected pregnant women with normal pregnant women in Dr. Soetomo General Hospital Surabaya. Bali Medical Journal, 11(3), 1059–1062.




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Margaretha Claudhya Febryanna
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BMJ Journal

Manggala Pasca Wardhana
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Muhammad Ilham Aldika Akbar
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Arif Rahman Nurdianto
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