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Characteristics of patients with acute lymphoblastic leukemia in 2016-2020 at Sanglah General Hospital, Bali

  • Evelin Vianetha Prima Snak ,
  • Ni Nyoman Mahartini ,
  • Sianny Herawati ,
  • Ni Kadek Mulyantari ,
  • Anak Agung Wiradewi Lestari ,

Abstract

Background: Acute lymphoblastic leukemia (ALL) is a bone marrow malignancy that is the most common cause of death in children. This study aims to determine the characteristics of ALL patients in 2016-2020 at Sanglah Hospital Denpasar, Bali.

Methods: This study used a retrospective descriptive study with secondary data from 166 patients. Variables assessed in this study included: demographic characteristics (age, gender, place of origin), complete blood count results include of hemoglobin levels, leukocyte (white blood cell) count, absolute neutrophil count, absolute lymphocyte count, thrombocyte count, and morphology subtype of ALL based on FAB classification from bone marrow aspiration (BMA).

Results: From demographic characteristics: most patients' age was in school-age children (>6 - <18 years) about 59.7%, dominated by male (60.2%), place of origin from Bali (71.7%) which is from Denpasar city (23.5%). From the laboratory results, complete blood count found that the most results are moderate anemia in children (54.7%), in adult female (70%), and in adult male (52.9%); leukocytosis in children (41%), in adult (77.8%); neutropenia in children (61.2%), in adult (59.3%); lymphocytosis in children (43.2%), in adult (81.5%); thrombocytopenia in children (97.1%), in adult (100%). From the results of the BMA examination, based on the FAB (French, American, and British) classification, the most common morphology of ALL was L2 subtype (78.9%).

Conclusion: Characteristics of patients with ALL at Sanglah General Hospital are dominated by children, male, from Denpasar, Bali, with laboratory results showing moderate anemia, leukocytosis, neutropenia, lymphocytosis, thrombocytopenia, and the most common morphological variants are ALL-L2 subtype.

References

  1. Pambudi B, Agustiani, C. Buku saku hematologi, leukosit dan kelainannya: Leukemia Limfoblastik Akut. In: Lembar S, Dony Y, Aprilia A, Tjahyadi CA, editors. 2nd Ed. Jakarta: Universitas Katolik Indonesia Atma Jaya; 2017.
  2. Coutre SE. Wintrobe’s clinical hematology: Acute lymphoblastic leukemia in adults. In: Greer JP, Rodger GM, Glader B, Arber DA, Means RT, List AF, et al, editors. 14th Ed. Philadelphia: Wolters Kluwer; 2019.
  3. Leclair SJ, Bentley G. Clinical laboratory hematology: Precursor Lymphoid Neoplasms. In: McKenzie SB, Williams JL, Piwowar KL, editors. 3rd Ed. New Jersey: Pearson Education; 2015.
  4. Hoffbrand AV, Moss PAH. Hoffbrand’s essential haematology: Acute lymphoblastic leukaemia. 7th Ed. UK: John Wiley & Son Ltd; 2016.
  5. Putri KW, Ugrasena IDG, Hernaningsih Y. Epidemiological study of clinical and laboratory profiles of patients with acute lymphoblastic leukemia at dr. soetomo hospital Surabaya. Biomolecular and Health Science Journal. 2019;02(01):48-52.
  6. Tarigan ADT, Ariawati K, Widnyana P. Prevalensi dan karakteristik anak dengan leukemia limfoblastik akut tahun 2011-2015 di RSUP Sanglah Denpasar. Medicina. 2019;50(2):391-5.
  7. Reddy P, Shankar R, Koshy T, Radhakrishnan V, Ganesan P, Jayachandran PK, et al. Evaluation of cytogenetic abnormalities in patients with acute lymphoblastic leukemia. Indian J Hematol Blood Transfus. 2019;35(4):640-8.
  8. Silva N, Masria S, Roekmantara T. Characteristic of patients with acute lymphoblastic leukemia (ALL) at al islam bandung hospital in 2017. Proseding Pendidikan Dokter. 2019;5(1):634-9.
  9. Kakaje A, Alhalabi MM, Ghareeb A, Karam B, Mansour B, Zahra B, et al. Rates and trends of childhood acute lymphoblastic leukaemia: an epidemiology study. Scientific Reports Nature Research. 2020;10:6756.
  10. Saleh R, Musa HH, Hamid GA. Epidemiological study of acute lymphoblastic leukemia in yemen. European Journal of Biomedical and Pharmaceutical Sciences. 2017;4(10):794-7.
  11. Saikia BJ, Roy PS, Kumar G, Mishra RK, Sarma A. Clinico-epidemiological features and response in childhood acute lymphoblastic leukemia at regional cancer center of northeast india. South Asian Journal of Cancer. 2019;8(4):241-3.
  12. Adinatha Y, Ariawati K. Gambaran karakteristik kanker anak di RSUP Sanglah, Bali, Indonesia periode 2008-2017. Intisari Sains Medis. 2020;11(2):575-581.
  13. Pahloosye A, Hashemi A, Mirmohammadi SJ, Atefi A. Presenting clinical and laboratory data of childhood acute lymphoblastic leukemia. Iranian Journal of Pediatric Hematology Oncology. 2011;1(3):71-7.
  14. Windiastuti E, Mulawi C. Gangguan metabolik pada leukemia limfositik akut dengan hiperleukositosis. Sari Pediatri. 2002;4(1):31-5.
  15. Biswal S, Godnaik C. Incidence and management of infections in patients with acute leukemia following chemotherapy in general wards. Ecancermedicalscience. 2013;7(310):1-16.
  16. Utami AAIAYT, Niruri R, Ariawati K. Pola kuman dan sensitivitas antibiotika pada anak dengan leukemia limfoblastik akut yang mengalami demam neutropenia. Jurnal Farmasi Udayana. 2013;2(3):67-72.
  17. Huang FL, Liao EC, Li CL, Yen CY, Yu SJ. Pathogenesis of pediatric b-cell acute lymphoblastic leukemia: Molecular pathway and disease treatments. Oncology Letters. 2020;20:448-454.
  18. Zuckerman T, Rowe JM. Pathogenesis and prognostication in acute lymphoblastic leukemia. Prime Reports. 2014;6(59):1-5.
  19. Sousa DWLD, Ferreira FVDA, Felix FHC, Lopes MVDO. Acute lymphoblastic leukemia in children and adolescent: prognostic factors and analysis of survival. Brazilian Journal of Hematology and Hemotherapy. 2015;37(4):223-9.
  20. Juniasari C, Fitriyani S, Afgani A, Yuniarti L, Triyani, Y. Klasifikasi morfologi leukemia limfoblastik akut berhubungan dengan kejadian relaps pada pasien anak. Jurnal Integrasi Kesehatan dan Sains. 2020;2(1):1-5.

How to Cite

Evelin Vianetha Prima Snak, Ni Nyoman Mahartini, Sianny Herawati, Ni Kadek Mulyantari, & Anak Agung Wiradewi Lestari. (2022). Characteristics of patients with acute lymphoblastic leukemia in 2016-2020 at Sanglah General Hospital, Bali. Bali Medical Journal, 11(2), 646–650. https://doi.org/10.15562/bmj.v11i2.3607

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Evelin Vianetha Prima Snak
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Ni Nyoman Mahartini
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Sianny Herawati
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Ni Kadek Mulyantari
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Anak Agung Wiradewi Lestari
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