Relationship between plasma adiponectin levels and cellulite

Sari Indriayani; Imam Budi Putra; Nelva Karmila Jusuf

doi:10.15562/bmj.v11i1.3634

Relationship between plasma adiponectin levels and cellulite

Sari Indriayani ,

Imam Budi Putra ,

Nelva Karmila Jusuf ,

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DOI: https://doi.org/10.15562/bmj.v11i1.3634 |
Published: 2022-04-30

Abstract

Background: Decreased adiponectin levels as a humoral vasodilator in subcutaneous adipose tissue in the cellulite area are thought to cause microcirculation disorders and tissue hypoxia, ultimately a local fibrotic response and collagen strands (septa) resulting in the appearance of cellulite. Adiponectin accumulates in the extracellular matrix. It is suspected that an increase in adiponectin levels can suppress the process of sclerotic fibrosis, thereby inhibiting the formation of cellulite. This study aimed to determine the relationship between plasma adiponectin levels and cellulite.

Methods: This study is an analytic observational study with a cross-sectional design involving 40 cellulite patients and 40 controls. Each patient underwent a history and dermatological examination. Then proceeded to assess plasma adiponectin levels from blood samples by ELISA test. These data were analyzed statistically using the Chi-square test.

Results: In this study, both cellulite and control patients were 20-30 years with the average plasma adiponectin level in cellulite was 8.07±3.94 µg/ml. The highest cellulite location in the femoral and gluteus areas was 62.5%. The results of this study showed that there was a statistically significant relationship between plasma adiponectin levels and cellulite (p = 0.025 < 0,05).

Conclusion: There is a significant relationship between low plasma adiponectin levels and the risk of cellulite.

References

Sadick Neil, Treatment for cellulite. International Journal of Women's Dermatology. 2019;68-72.
Uebel CO, Piccinini PS, Martinelli A, Aguiar DF, Ramos RFM. Cellulite: A Surgical Treatment Approach. Aesthetic Surg J. 2018; 38(10): 1099-114.
Hexsel D, Mazzuco Roemarie. Cellulite. (eds) Update in Cosmetic Dermatology. Springer-Verlag Berlin Heidelberg. 2013;(2) 21-32.
Tokarska Kamila, Tokarska Slawomir, Wozniacka Anna. Cellulite: a cosmetic or systemic issue? Contemporary views on the etiopathogenesis of cellulite. Advances in Dermatology and Allergology. 2018; XXXV (5):442-46.
Friedmann DP, Vick GL, Mishra V. Cellulite: A review with a focus on subcision. Clinical, Cosmetic and Investigational Dermatology. 2017; 10: 17–23.
Leszko M. Cellulite in menopause. Menopause review. Przeglad Menopauzlny. 2014; 13(5):298-304.
Bacci PA, Leibaschoff. Pathophysiology of Cellulite. In: Cellulite Pathophysiology and Treatment. Goldman MP, Bacci PA, eds. New York: Taylor & Francis Group. 2006.
Khan M, Bolotin D, Saedi N. Cellulite: Anatomy, Etiology, Treatment Indications. in Body shaping skin,fat, cellulite. 2016; (12): 99-105.
Emanuele Enzo, Minoretti Piercarlo, Altabas Karmela. Adiponectin expression in subcutaneous adipose tissue is reduced in women with cellulite. International Journal of Dermatology. 2011;412-16.
Hexsel D, de Oliveira Dal'Forno T, Cignachi S. Definition, Clinical Aspects, Associated Conditions, and Differential Diagnosis. In: Cellulite Pathophysiology and Treatment. Goldman MP, Bacci PA, eds. New York: Taylor & Francis Group. 2006. 7-24.
Triawanti T. Molecular Adipocyte: Konsep Dasar Fisiologi dan Patologi. Airlangga University Press. 2017;1-75.
Chandran M, Phillips SA, Ciaraldi T, Henry RR. Adiponectin: More than just another fat cell hormone? Diabetes Care. 2003; 26(8): 2442–50.
Afonso JPJM, de Mello Tucunduva TC, Pinheiro MV, Bagatin E. Cellulite: a review. Surg Cosmet Dermatol. 2010; 2(3): 214-19.
Krenning G, Moonen JR AJ, Harmsen MC, Pleiotropism of Adiponectin, inflammation, neovascular, and fibrosis. Circulation Research. Volume 104, 2009;1029-1031.
Prokopiev V, Durmishev L, Miteva L. Collagen and it's role as "the good, the bad and the ugly" in cellulite pathogenesis and treatment. Medinfo ltd. Bulgaria. 2018, Vol.6; 1-9.
Emanuele E, Cellulite: Advantaces in treatment: Fact and controversies. Clinics in Dermatologi. 2013;(31) 725-30.
Gulec A Tulin. Treatment of Cellulite with LPG Endermologie. International Journal of Dermatology. 2009;265-70.
Putri Elsi Kemala. Perbedaan Karakteristik Dermatoglifi Ujung Jari dan Telapak Tangan Perempuan Etnis Minang Kabau yang Menderita Selulit dengan Tangan Perempuan Tanpa Selulit. Dalam: Tesis Fakultas Kedokteran Universitas Andalas. RSUP M.Djamil .Padang. 2018
Nurnberger F, Muller G. So-Called Cellulite: An Invented Disease. J Dermatol Surg Oncol. 1978;4(3):221–29.
Kravitz L & Achenbach NJ. Cellulite: A Review of its Anatomy, Physiology and Treatment. IDEA Fitness Journal. 2010;7(4):36-43.
Whipple Lauren A, Fournier Graig T, Heiman Adee J, Awad Amanda A, Roth Malxolm Z, et al, The Anatomical Basis of cellulite Dimple Formation: An Ultrasound-Based Examination. J, Plastic and Reconstructive Surgery. 2021;375e-81e.
Schweritz C, Braun-Falco O. So-Called Cellulite. Journal of Dermatol.Surg.Oncol. 1978;4:230- 4.
Del Pino E, Rosado R, Auela A, Guzman G, Arguelles D, et al, effect of controlled volumetric tissue heating with radiofrequency on cellulite and the subcutaneous tissue of the buttocks and thighs. Journal of Drugs in Dermatology, 2006;5(8):714-22
Silva FM, De Almeida JC, Feoli AM. Effect of diet on adiponectin levels in blood. Nutr Rev. 2011; 69(10): 599–612.
Shehzad A, Iqbal W, Shehzad O, Lee YS. Adiponectin: Regulation of its production and its role in human diseases. Hormones. 2012; 11(1): 8–20.
Emanuele E, Bertona M, Geroldi D. A multilocus candidate approach identifies ACE and HIF1A as susceptibilty genes for cellulite. Journal of European Academy of Dermatology and Venereology. 2010; 930-35.
Rossi ABR, Vergnanini AL. Cellulite: A review. Journal of European Academy of Dermatology and Venereology. 2000; 14:251-62.
De Godoy JMP, De Godoy Maria de FG. Physiopathological Hypothesis of Cellulite. The Open Cardiovascular Medicine Journal. 2009;(3);96-97.

[1] Sadick Neil, Treatment for cellulite. International Journal of Women's Dermatology. 2019;68-72.

[2] Uebel CO, Piccinini PS, Martinelli A, Aguiar DF, Ramos RFM. Cellulite: A Surgical Treatment Approach. Aesthetic Surg J. 2018; 38(10): 1099-114.

[3] Hexsel D, Mazzuco Roemarie. Cellulite. (eds) Update in Cosmetic Dermatology. Springer-Verlag Berlin Heidelberg. 2013;(2) 21-32.

[4] Tokarska Kamila, Tokarska Slawomir, Wozniacka Anna. Cellulite: a cosmetic or systemic issue? Contemporary views on the etiopathogenesis of cellulite. Advances in Dermatology and Allergology. 2018; XXXV (5):442-46.

[5] Friedmann DP, Vick GL, Mishra V. Cellulite: A review with a focus on subcision. Clinical, Cosmetic and Investigational Dermatology. 2017; 10: 17–23.

[6] Leszko M. Cellulite in menopause. Menopause review. Przeglad Menopauzlny. 2014; 13(5):298-304.

[7] Bacci PA, Leibaschoff. Pathophysiology of Cellulite. In: Cellulite Pathophysiology and Treatment. Goldman MP, Bacci PA, eds. New York: Taylor & Francis Group. 2006.

[8] Khan M, Bolotin D, Saedi N. Cellulite: Anatomy, Etiology, Treatment Indications. in Body shaping skin,fat, cellulite. 2016; (12): 99-105.

[9] Emanuele Enzo, Minoretti Piercarlo, Altabas Karmela. Adiponectin expression in subcutaneous adipose tissue is reduced in women with cellulite. International Journal of Dermatology. 2011;412-16.

[10] Hexsel D, de Oliveira Dal'Forno T, Cignachi S. Definition, Clinical Aspects, Associated Conditions, and Differential Diagnosis. In: Cellulite Pathophysiology and Treatment. Goldman MP, Bacci PA, eds. New York: Taylor & Francis Group. 2006. 7-24.

[11] Triawanti T. Molecular Adipocyte: Konsep Dasar Fisiologi dan Patologi. Airlangga University Press. 2017;1-75.

[12] Chandran M, Phillips SA, Ciaraldi T, Henry RR. Adiponectin: More than just another fat cell hormone? Diabetes Care. 2003; 26(8): 2442–50.

[13] Afonso JPJM, de Mello Tucunduva TC, Pinheiro MV, Bagatin E. Cellulite: a review. Surg Cosmet Dermatol. 2010; 2(3): 214-19.

[14] Krenning G, Moonen JR AJ, Harmsen MC, Pleiotropism of Adiponectin, inflammation, neovascular, and fibrosis. Circulation Research. Volume 104, 2009;1029-1031.

[15] Prokopiev V, Durmishev L, Miteva L. Collagen and it's role as "the good, the bad and the ugly" in cellulite pathogenesis and treatment. Medinfo ltd. Bulgaria. 2018, Vol.6; 1-9.

[16] Emanuele E, Cellulite: Advantaces in treatment: Fact and controversies. Clinics in Dermatologi. 2013;(31) 725-30.

[17] Gulec A Tulin. Treatment of Cellulite with LPG Endermologie. International Journal of Dermatology. 2009;265-70.

[18] Putri Elsi Kemala. Perbedaan Karakteristik Dermatoglifi Ujung Jari dan Telapak Tangan Perempuan Etnis Minang Kabau yang Menderita Selulit dengan Tangan Perempuan Tanpa Selulit. Dalam: Tesis Fakultas Kedokteran Universitas Andalas. RSUP M.Djamil .Padang. 2018

[19] Nurnberger F, Muller G. So-Called Cellulite: An Invented Disease. J Dermatol Surg Oncol. 1978;4(3):221–29.

[20] Kravitz L & Achenbach NJ. Cellulite: A Review of its Anatomy, Physiology and Treatment. IDEA Fitness Journal. 2010;7(4):36-43.

[21] Whipple Lauren A, Fournier Graig T, Heiman Adee J, Awad Amanda A, Roth Malxolm Z, et al, The Anatomical Basis of cellulite Dimple Formation: An Ultrasound-Based Examination. J, Plastic and Reconstructive Surgery. 2021;375e-81e.

[22] Schweritz C, Braun-Falco O. So-Called Cellulite. Journal of Dermatol.Surg.Oncol. 1978;4:230- 4.

[23] Del Pino E, Rosado R, Auela A, Guzman G, Arguelles D, et al, effect of controlled volumetric tissue heating with radiofrequency on cellulite and the subcutaneous tissue of the buttocks and thighs. Journal of Drugs in Dermatology, 2006;5(8):714-22

[24] Silva FM, De Almeida JC, Feoli AM. Effect of diet on adiponectin levels in blood. Nutr Rev. 2011; 69(10): 599–612.

[25] Shehzad A, Iqbal W, Shehzad O, Lee YS. Adiponectin: Regulation of its production and its role in human diseases. Hormones. 2012; 11(1): 8–20.

[26] Emanuele E, Bertona M, Geroldi D. A multilocus candidate approach identifies ACE and HIF1A as susceptibilty genes for cellulite. Journal of European Academy of Dermatology and Venereology. 2010; 930-35.

[27] Rossi ABR, Vergnanini AL. Cellulite: A review. Journal of European Academy of Dermatology and Venereology. 2000; 14:251-62.

[28] De Godoy JMP, De Godoy Maria de FG. Physiopathological Hypothesis of Cellulite. The Open Cardiovascular Medicine Journal. 2009;(3);96-97.

Relationship between plasma adiponectin levels and cellulite

Abstract

References

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