Background: Decreased adiponectin levels as a humoral vasodilator in subcutaneous adipose tissue in the cellulite area are thought to cause microcirculation disorders and tissue hypoxia, ultimately a local fibrotic response and collagen strands (septa) resulting in the appearance of cellulite. Adiponectin accumulates in the extracellular matrix. It is suspected that an increase in adiponectin levels can suppress the process of sclerotic fibrosis, thereby inhibiting the formation of cellulite. This study aimed to determine the relationship between plasma adiponectin levels and cellulite.
Methods: This study is an analytic observational study with a cross-sectional design involving 40 cellulite patients and 40 controls. Each patient underwent a history and dermatological examination. Then proceeded to assess plasma adiponectin levels from blood samples by ELISA test. These data were analyzed statistically using the Chi-square test.
Results: In this study, both cellulite and control patients were 20-30 years with the average plasma adiponectin level in cellulite was 8.07±3.94 µg/ml. The highest cellulite location in the femoral and gluteus areas was 62.5%. The results of this study showed that there was a statistically significant relationship between plasma adiponectin levels and cellulite (p = 0.025 < 0,05).
Conclusion: There is a significant relationship between low plasma adiponectin levels and the risk of cellulite.