ORIGINAL ARTICLE

Detection of hepatitis B virus in clinically suspected infectious hepatitis pregnant and non-pregnant women

Salman Khan

Salman Khan
Department of Microbiology Santosh medical college Santosh University, Ghaziabad, India. Email: salman186631@gmail.com
Online First: August 04, 2017 | Cite this Article
Khan, S. 2017. Detection of hepatitis B virus in clinically suspected infectious hepatitis pregnant and non-pregnant women. Bali Medical Journal 6(3): S105-S108. DOI:10.15562/bmj.v6i3.366


Background: Vertical transmission of HBV from infected mothers to their offspring, either in peripartum or in utero, remains a major source of perpetuating reservoir of chronically infected individuals globally. Objectives: To determine the prevalence of HBsAg & HBeAg in clinically suspected infectious hepatitis in pregnant women at a tertiary care hospital in Ghaziabad. Material and Method: This prospective study was conducted on 188 patients between age ranges 18–65 years in Department of Microbiology at Santosh Medical College, Ghaziabad between December 2014 to June 2016. 5 ml blood samples were taken from each patient suspected of acute infectious hepatitis were analyzed. The sera were separated and screened for HBsAg by immune-chromatographic card then positive serum samples for HBsAg were again tested for HBsAg using ELISA kit. The positive sample for HBsAg in pregnant was tested for hepatitis B e antigen (HBeAg) by ELISA test. Results: HBsAg were identified in 11(5.85%) female samples. Among them,7 (3.72%) were from 21-35 years age groups, this was statistically significant (P<0.05), compared to the other age groups. From 11 HBsAg positive female, six were pregnant, and the prevalence of HBsAg-positive pregnant female is 3.19%. 4 female were positive for HBeAg and prevalence of HBeAg-positive pregnant woman is 2.13%. 75%(n=3) HBeAg-positive case was found in the age group of 21-35, this was statistically significant (P<0.05), compared to the other age groups. Conclusions: Study showed that HBV is prevalent in pregnant women. Screening & vaccination should be considered by health policy makers to prevent transmission of HBV

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