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Successful treatment of intravenous immunoglobulin for Toxic Epidermal Necrolysis (TEN) associated with COVID-19 infection and vaccination: case reports

  • Desy Wulandari ,
  • Ricky Pebriansyah ,
  • Azwin Mengindra Putera Lubis ,
  • Zahrah Hikmah ,
  • Anang Endaryanto ,


Background: Toxic Epidermal Necrolysis (TEN) are rare but potentially life-threatening disorder. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of COVID-19 disease with various clinical manifestations. Two cases of TEN were reported in pediatric patients. The causal relationship between COVID-19 infection and vaccination against TEN has not been fully understood.

Case presentation: This study reports a case of a child with COVID-19 who was admitted to a pediatric hospital ward with TEN which occupies > 30% of total body surface area, and one case that suffered from TEN due to COVID-19 vaccination. All patients received IVIG 0.5 g / kg / day for 3 consecutive days.

Conclusion: The child was treated with intravenous immunoglobulin with a good outcome and clinical improvement.


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How to Cite

Desy Wulandari, Ricky Pebriansyah, Azwin Mengindra Putera Lubis, Zahrah Hikmah, & Anang Endaryanto. (2022). Successful treatment of intravenous immunoglobulin for Toxic Epidermal Necrolysis (TEN) associated with COVID-19 infection and vaccination: case reports. Bali Medical Journal, 11(2), 957–961.




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Desy Wulandari
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Ricky Pebriansyah
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Azwin Mengindra Putera Lubis
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Zahrah Hikmah
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Anang Endaryanto
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