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Systemic Lupus Erythematosus Flare Triggered by COVID-19 Infection: A Case-Based Review

  • Maria Sarce Tio ,
  • Arundina Sanyoto ,


Introduction: The coronavirus disease 19 (COVID-19) and autoimmune disease has been associated bidirectionally, several reports has shown COVID-19 precipitate an exacerbation of an autoimmune disease that has already stable. Recognize and treatment of flare in SLE condition with COVID-19 is challenging in this pandemic era. This review aims to report a case SLE patient who experienced severe flares after being infected with COVID-19 and review of the literature.

Case report: We presented a 27-year-old female with a history of Systemic Lupus Erythematosus (SLE) who experienced severe flares after being infected with COVID-19 and a review.

Methods and Results: A total of 72 potentially relevant citations were identified. After removing the duplicate citations, the title, and abstracts of 61 articles were evaluated and 11 relevant articles were reviewed in detail. A total of 72 potentially relevant citations were identified. After removing the duplicate citations, the title, and abstracts of 61 articles were evaluated and 11 relevant articles were included.

Conclusion: The COVID-19 pandemic is a devastating situation all over the world. SLE patient has already been in a susceptible condition as the disease progressed and continued having immunosuppressant therapy also one of the risk factors. A Flare condition can be happened during the COVID-19 Infection or after the infection is resolved. In SLE patient having COVI-19, close monitoring, high adherence to the therapy, and the health protocol are needed.


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How to Cite

Tio, M. S., & Sanyoto, A. (2022). Systemic Lupus Erythematosus Flare Triggered by COVID-19 Infection: A Case-Based Review. Bali Medical Journal, 11(3), 1448–1455.




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