Skip to main content Skip to main navigation menu Skip to site footer

Maternal serum docosahexaenoic acid (DHA) levels as a predictor of preeclampsia risk in urban and rural areas of developing country

  • Safinaz ,
  • Budi Prasetyo ,
  • Agus Sulistyono ,
  • Muhammad Yusuf ,
  • Erry Gumilar Dachlan ,
  • Muhammad Dikman Angsar ,

Abstract

Preeclampsia is one of the maternal health outcomes that can be influenced by nutritional status during pregnancy. Globally, preeclampsia afflicts 4.6% of all pregnancies and constitutes a significant contributor to maternal morbidity and mortality. Prior investigations have proposed that the administration of DHA supplements during pregnancy could offer a potential means to avert and manage specific pregnancy-related complications. Women living in urban and rural areas in developing countries, including Indonesia, may have poor food habits characterized by a low consumption of animal products. Pregnant women in urban areas were found to consume less meat, fish, and eggs. A lack of certain nutrients in the diet, such as docosahexaenoic acid (DHA), may also increase the risk of preeclampsia in pregnant women. This literature review aims to investigate maternal DHA levels as a predictor factor in preeclampsia risk in urban and rural areas of developing countries.

References

  1. Abalos E, Cuesta C, Grosso AL, Chou D, Say L. Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol. 2013 Sep;170(1):1-7. doi: 10.1016/j.ejogrb.2013.05.005.
  2. Zhang N, Tan J, Yang H, Khalil RA. Comparative risks and predictors of preeclamptic pregnancy in the Eastern, Western and developing world. Biochem Pharmacol. 2020 Dec;182:114247. doi: 10.1016/j.bcp.2020.114247.
  3. Arvizu M, Afeiche MC, Hansen S, Halldorsson TF, Olsen SF, Chavarro JE. Fat intake during pregnancy and risk of preeclampsia: a prospective cohort study in Denmark. Eur J Clin Nutr. 2019 Jul;73(7):1040-1048. doi: 10.1038/s41430-018-0290-z.
  4. Taylor RM, Fealy SM, Bisquera A, Smith R, Collins CE, Evans TJ, Hure AJ. Effects of Nutritional Interventions during Pregnancy on Infant and Child Cognitive Outcomes: A Systematic Review and Meta-Analysis. Nutrients. 2017 Nov 20;9(11):1265. doi: 10.3390/nu9111265.
  5. Wibowo N, Irwinda R, Bardosono S, Prameswari N, Putri AS, Syafitri I. Long-chain polyunsaturated fatty acid status in first-trimester pregnant women. Med J Indones. 2018 Oct 12;27(3):155–60.
  6. Irwinda R, Hiksas R, Siregar AA, Saroyo YB, Wibowo N. Long-chain polyunsaturated fatty acid (LCPUFA) status in severe preeclampsia and preterm birth: a cross sectional study. Sci Rep. 2021 Jul 19;11(1):14701.
  7. Asifa C, Rodiani R. Suplementasi Docosahexaenoic Acid (Dha) Sebagai Usaha Preventif Ibu Hamil Dengan Risiko Preeklampsia. J Kesehat. 2021 Jun 30;14(1):78–85.
  8. Devarshi PP, Grant RW, Ikonte CJ, Hazels Mitmesser S. Maternal Omega-3 Nutrition, Placental Transfer and Fetal Brain Development in Gestational Diabetes and Preeclampsia. Nutrients. 2019 May 18;11(5):1107.
  9. Perkumpulan Obstetri dan Ginekologi Indonesia. Pedoman nasional pelayanan kedokteran: diagnosis dan tata laksana preeklampsia. Himpunan Kedokteran Feto Maternal. 2016;1–59.
  10. Wang W, Xie X, Yuan T, Wang Y, Zhao F, Zhou Z, et al. Epidemiological trends of maternal hypertensive disorders of pregnancy at the global, regional, and national levels: a population‐based study. BMC Pregnancy Childbirth. 2021 Dec 8;21(1):364.
  11. Roberts JM, Hubel CA. The Two Stage Model of Preeclampsia: Variations on the Theme. Placenta. 2009 Mar;30:32–7.
  12. Cunningham F, Leveno KJ, Bloom SL, Spong CY and Dashe JS. William Obstetric 25 th Edition Chapter 11: Preterm Birth p803-834. New York: Mc Graw Hill. 2018.
  13. Karumanchi SA, Lim K and August P. Preeclampsia: Pathogenesis. UpToDate. Waltham, MA: UpToDate Inc, 2020. pp. 1–32.
  14. Poon LCY, Kametas NA, Maiz N, Akolekar R, Nicolaides KH. First-Trimester Prediction of Hypertensive Disorders in Pregnancy. Hypertension. 2009 May;53(5):812–8.
  15. Bartsch E, Medcalf KE, Park AL, Ray JG. Clinical risk factors for preeclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies. BMJ. 2016 Apr 19;353:i1753.
  16. Haeru AS, Wibowo. Energy Intake, Macro Nutrition and Nutritional Status of Preeclampsia Patients in The RSIA Siti Fatimah, Makassar. Heal Notions. 2019;3(2):107–13.
  17. Xu H, Bryna Shatenstein, Luo ZC, Wei SQ, Fraser WD. Role of nutrition in the risk of preeclampsia. 2009 Nov 1 [cited 2023 May 17];67(11):639–57. Available from: https://academic.oup.com/nutritionreviews/article/67/11/639/1851048
  18. Carvajal JA. Docosahexaenoic Acid Supplementation Early in Pregnancy May Prevent Deep Placentation Disorders. Biomed Res Int. 2014;2014:1–10.
  19. Jiang Y, Chen Y, Wei L, Zhang H, Zhang J, Zhou X, et al. DHA supplementation and pregnancy complications. J Transl Med. 2023 Jun 17;21(1):394.
  20. Jackson K, Harris W. A Prenatal DHA Test to Help Identify Women at Increased Risk for Early Preterm Birth: A Proposal. Nutrients. 2018 Dec 6;10(12):1933.
  21. Bakouei F, Delavar MA, Mashayekh-Amiri S, Esmailzadeh S, Taheri Z. Efficacy of n-3 fatty acids supplementation on the prevention of pregnancy induced-hypertension or preeclampsia: A systematic review and meta-analysis. Taiwan J Obstet Gynecol. 2020 Jan;59(1):8–15.
  22. Aparicio E, Martín-Grau C, Hernández-Martinez C, Voltas N, Canals J, Arija V. Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy. BMC Pregnancy Childbirth. 2021 Dec 17;21(1):778.
  23. Angkasa D, Tambunan V, Khusun H, Witjaksono F, Agustina R. Inadequate dietary α-linolenic acid intake among Indonesian pregnant women is associated with lower newborn weights in urban Jakarta. Asia Pac J Clin Nutr. 2017;26(1):S9–18.
  24. Dangat KD, Mehendale SS, Yadav HR, Kilari AS, Kulkarni A V., Taralekar VS, et al. Long-Chain Polyunsaturated Fatty Acid Composition of Breast Milk in Pre-Eclamptic Mothers. Neonatology. 2010;97(3):190–4.
  25. Kulkarni AV, Mehendale SS, Yadav HR, Kilari AS, Taralekar VS, Joshi SR. Circulating angiogenic factors and their association with birth outcomes in preeclampsia. Hypertens Res. 2010 Jun 12;33(6):561–7.
  26. Hariraj V. Assessment Of Maternal Serum Docosahexaenoic Acid Levels In Preeclampsia And Uncomplicated Pregnancies. 2021;1–119.
  27. Imhoff‐Kunsch B, Briggs V, Goldenberg T, Ramakrishnan U. Effect of n‐3 Long‐chain Polyunsaturated Fatty Acid Intake during Pregnancy on Maternal, Infant, and Child Health Outcomes: A Systematic Review. Paediatr Perinat Epidemiol. 2012 Jul 28;26(s1):91–107.
  28. Von Schacky C. Omega-3 index in 2018/19. Proc Nutr Soc. 2020 Nov 11;79(4):381–7.

How to Cite

Safinaz, Budi Prasetyo, Agus Sulistyono, Muhammad Yusuf, Erry Gumilar Dachlan, & Muhammad Dikman Angsar. (2024). Maternal serum docosahexaenoic acid (DHA) levels as a predictor of preeclampsia risk in urban and rural areas of developing country. Bali Medical Journal, 13(2), 576–581. https://doi.org/10.15562/bmj.v13i2.4936

HTML
6

Total
2

Share

Search Panel