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Comparison of the immunomodulatory potential of tuber extracts Purple Sweet Potato (Ipomoea batatas L) and Sembung leaf extract (Blumea balsamifera L) in an oxidative stress rat model induced by maximum physical activity


Link of Video Abstract:


Background: Heavy physical activity causes changes in the distribution of leukocyte subpopulations due to oxidative stress. Research shows decreased CD4 due to heavy physical activity and increased pro-inflammatory interleukins. This study aimed to compare the benefits of exogenous antioxidants from two medicinal plant extracts, purple sweet potato tuber extract and sembung leaf extract, in the maximal swimming rat model.

Methods: The research subjects were 27 adult Wistar rats divided into 3 groups using a randomized posttest-only control group design. The mice were divided into 3 groups, namely the control group (9 animals), which was not given purple sweet potato tuber extract or sembung leaf extract. Treatment group 1 (9 animals) was given 200 mg/day of purple sweet potato tuber extract for 2 weeks. Treatment group 2 (9 animals) was given sembung leaf extract at 4 mg/day for 2 weeks. After 2 weeks of administering the extract, all mice swam for 30 minutes (until they nearly drowned). After swimming, blood was examined for TNF-α, CD4, hematopoietic stem cells, and MDA. The data obtained was analyzed using the ANOVA test to see differences between groups.

Results: The results showed that CD4 cells for the group given sembung leaf extract were higher but not significant (p>0.05). HSC (Hematopoietic Stem Cell) cells were higher than the control group (p<0.05) in both treatment groups. MDA and TNFα levels were highest in the control group compared to the treatment group (p<0.05) and did not differ between the two treatment groups (p>0.05).

Conclusion: The conclusion of the research was that giving purple sweet potato tuber extract and sembung leaf extract both caused higher HSC and lower MDA and TNFα, so both test ingredients were immunostimulators, antioxidants, and anti-inflammatory.


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How to Cite

Yasa, I. W. P. S., Subawa, A. A. N., & Jawi, I. M. (2024). Comparison of the immunomodulatory potential of tuber extracts Purple Sweet Potato (Ipomoea batatas L) and Sembung leaf extract (Blumea balsamifera L) in an oxidative stress rat model induced by maximum physical activity. Bali Medical Journal, 13(2), 649–653.




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