Skip to main content Skip to main navigation menu Skip to site footer

Efficacy of combination therapy 5% permethrin cream and precipitated sulfur (ointment 2-4) compared with single therapy of 5% permethrin cream in children

  • Frizka Eliza ,
  • Muhammad Yulianto Listiawan ,
  • Sawitri ,
  • Cita Rosita Sigit Prakoeswa ,
  • Evy Ervianti ,
  • Budi Utomo ,
  • Damayanti ,
  • Erik Rizka Yulianggoro ,

Abstract

Introduction: Scabies is a skin infestation with the main pruritus symptom caused by Sarcoptes scabiei. The common complaints are discomfort due to itching and a picture of lesions on the skin in the form of papules, pustules, or vesicles. The study aims to analyze the comparative efficacy of using a combination therapy of 5% permethrin cream and precipitated sulfur (ointment 2-4) compared with single therapy of 5% permethrin cream in pediatric scabies patients at the Outpatient Clinic Dr. Soetomo General Academic Hospital in the 2019-2020 period.

Methods: This study is an analytical study using a cross-sectional retrospective method, which aims to compare the effectiveness of using a combination of 5% permethrin cream and precipitated sulfur(ointment 2-4) compared to 5% permethrin cream as a single therapy. Study data were processed using SPSS, followed by univariate and bivariate analyses using statistical methods and comparative tests.

Results: This study found 88 new scabies patients, with the number of patients who received permethrin single therapy as many as 43 patients (51.1%), while those who received combination therapy were 45 patients (48.9%). Scabies treatment using combination therapy has better effectiveness than single therapy 5% permethrin cream when seen from the absence of new complaints and improvement of skin lesions after receiving treatment. Analysis of therapy results for the emergence of new complaints with a p-value of 0.010 showed significant results. Analysis of the results of therapy seen in skin lesions improved on single therapy with a p-value of 0.014, indicating significant results.

Conclusion: Significant results were found in the group that received combination therapy treatment seen from the improvement of skin lesions and no new lesions were found, while there were no significant comparison results when seen from complaints of itching

References

  1. Leung AKC, Lam JM, Leong KF. Scabies: A Neglected Global Disease. Curr Pediatr Rev. 2020;16(1):33-42. doi: 10.2174/1573396315666190717114131.
  2. Retha R, Sawitri S. Scabies in Children: A Retrospective Study. BIKK. 2020;32(1):55.
  3. Anderson KL, Strowd LC. Epidemiology, Diagnosis, and Treatment of Scabies in a Dermatology Office. J Am Board Fam Med. 2017;30(1):78–84.
  4. Usha V, Gopalakrishnan Nair TV. A comparative study of oral ivermectin and topical permethrin cream in the treatment of scabies. J Am Acad Dermatol. 2000;42(2):236-40. doi: 10.1016/S0190-9622(00)90131-2.
  5. Hay RJ, Steer AC, Engelman D, Walton S. Scabies in the developing world--its prevalence, complications, and management. Clin Microbiol Infect. 2012;18(4):313-23. doi: 10.1111/j.1469-0691.2012.03798.x.
  6. Mumcuoglu KY, Gilead L, Ingber A. New insights in pediculosis and scabies. Expert Review of Dermatology. 2009;4(3):285–302.
  7. Dagne H, Dessie A, Destaw B, Yallew WW, Gizaw Z. Prevalence and associated factors of scabies among schoolchildren in Dabat district, northwest Ethiopia, 2018. Environ Health Prev Med. 2019;24(1):67. doi: 10.1186/s12199-019-0824-6.
  8. Aukerman W, Curfman K, Urias D, Shayesteh K. Norwegian Scabies management after prolonged disease course: A case report. Int J Surg Case Rep. 2019;61:180-183. doi: 10.1016/j.ijscr.2019.07.025.
  9. Engelman D, Yoshizumi J, Hay RJ, Osti M, Micali G, Norton S, Walton S, Boralevi F, Bernigaud C, Bowen AC, Chang AY, Chosidow O, Estrada-Chavez G, Feldmeier H, Ishii N, Lacarrubba F, Mahé A, Maurer T, Mahdi MMA, Murdoch ME, Pariser D, Nair PA, Rehmus W, Romani L, Tilakaratne D, Tuicakau M, Walker SL, Wanat KA, Whitfeld MJ, Yotsu RR, Steer AC, Fuller LC. The 2020 International Alliance for the Control of Scabies Consensus Criteria for the Diagnosis of Scabies. Br J Dermatol. 2020;183(5):808-820. doi: 10.1111/bjd.18943.
  10. Engelman D, Cantey PT, Marks M, Solomon AW, Chang AY, Chosidow O, Enbiale W, Engels D, Hay RJ, Hendrickx D, Hotez PJ, Kaldor JM, Kama M, Mackenzie CD, McCarthy JS, Martin DL, Mengistu B, Maurer T, Negussu N, Romani L, Sokana O, Whitfeld MJ, Fuller LC, Steer AC. The public health control of scabies: priorities for research and action. Lancet. 2019;394(10192):81-92. doi: 10.1016/S0140-6736(19)31136-5.
  11. Engelman D, Kiang K, Chosidow O, McCarthy J, Fuller C, Lammie P, Hay R, Steer A; Members Of The International Alliance For The Control of Scabies. Toward the global control of human scabies: introducing the International Alliance for the Control of Scabies. PLoS Negl Trop Dis. 2013;7(8):e2167. doi: 10.1371/journal.pntd.0002167.
  12. Currie BJ. Scabies and Global Control of Neglected Tropical Diseases. N Engl J Med. 2015 Dec 10;373(24):2371–2.
  13. Ibraheem NM. Controlled Clinical Trials: Comparison The efficacy of some Single Topical Scabies Treatment Modalities versus Combined Topical Modalities. Rese Jour of Pharm and Technol. 2019;12(3):1361. doi: 10.5958/0974-360X.2019.00229.4
  14. Golant AK, Levitt JO. Scabies: a review of diagnosis and management based on mite biology. Pediatr Rev. 2012;33(1):e1-e12. doi: 10.1542/pir.33-1-e1.
  15. Arlian LG, Morgan MS. A review of Sarcoptes scabiei: past, present and future. Parasit Vectors. 2017;10(1):297. doi: 10.1186/s13071-017-2234-1.
  16. Osti MH, Sokana O, Lake S, Whitfeld MJ, Boara D, Nasi T, Dauer S, Marks M, Romani L, Kaldor JM, Steer AC, Engelman D. The body distribution of scabies skin lesions. JEADV Clinical Practice. 2022;1(2), 111-121. https://doi.org/10.1002/jvc2.26.
  17. Kim M, Kim SK, Hong MJ, Kwak SH, Kim EO, Bae M, Kim MJ, Lee WJ, Kim SH, Jung J, Chang SE. Importance of Follow-Up Microscopic Examination in Hospitalized Patients with Confirmed Scabies. Am J Trop Med Hyg. 2020;103(6):2539-2541. doi: 10.4269/ajtmh.20-0318.
  18. Jastaniah MWA, Zimmo ZFK, Bakallah MWS, Hantoush MSS, Abdal-Aziz M. Clinical presentation and risk factors of increased scabies cases in the Western region of Saudi Arabia in 2016-2018. Saudi Med J. 2019;40(8):820-827. doi: 10.15537/smj.2019.8.24360.
  19. Lassa S, Campbell MJ, Bennett CE. Epidemiology of scabies prevalence in the U.K. from general practice records. Br J Dermatol. 2011;164(6):1329-34. doi: 10.1111/j.1365-2133.2011.10264.x.
  20. Melo ED, Ribas CBDR, Encarnação ICL. Digital dermoscopy: a complementary method in the diagnosis of scabies. An Bras Dermatol. 2020;95(5):638-640. doi: 10.1016/j.abd.2019.11.014.

How to Cite

Frizka Eliza, Listiawan, M. Y. ., Sawitri, Prakoeswa, C. R. S. ., Ervianti, E. ., Utomo, B. ., Damayanti, & Yulianggoro, E. R. . (2024). Efficacy of combination therapy 5% permethrin cream and precipitated sulfur (ointment 2-4) compared with single therapy of 5% permethrin cream in children. Bali Medical Journal, 13(1), 918–923. https://doi.org/10.15562/bmj.v13i1.5285

HTML
12

Total
7

Share

Search Panel