ORIGINAL ARTICLE

Blood superoxide dismutase (SOD) level has a negative correlation with dry eye (DE) degree

Niti K. Susila , N. M. Mahayani, A. A. Triningrat, I. G. Widiana, A. A. Djelantik, W. G. Jayanegara

Niti K. Susila
Department of Ophthalmology, Udayana Faculty of Medicine/Sanglah General Hospital Denpasar. Email: susilank@gmail.com

N. M. Mahayani
Department of Ophthalmology, Udayana Faculty of Medicine/Sanglah General Hospital Denpasar

A. A. Triningrat
Department of Ophthalmology, Udayana Faculty of Medicine/Sanglah General Hospital Denpasar

I. G. Widiana
Department of Internal Medicine, Udayana Faculty of Medicine/Sanglah General Hospital Denpasar

A. A. Djelantik
Department of Ophthalmology, Udayana Faculty of Medicine/Sanglah General Hospital Denpasar

W. G. Jayanegara
Department of Ophthalmology, Udayana Faculty of Medicine/Sanglah General Hospital Denpasar
Online First: May 18, 2017 | Cite this Article
Susila, N., Mahayani, N., Triningrat, A., Widiana, I., Djelantik, A., Jayanegara, W. 2017. Blood superoxide dismutase (SOD) level has a negative correlation with dry eye (DE) degree. Bali Medical Journal 6(2): 390-394. DOI:10.15562/bmj.v6i2.562


Background: The therapy for dry eye (DE) remains controversial. Some studies concluded that the ideal therapy for DE is based etiopathogenesis. Dry eye is caused by a decrease in antioxidant level; one of them is superoxide dismutase (SOD). This study assessed the correlation between SOD level and DE degree as therapy based on the etiopathogenesis of DE.

Method: This study was a cross-sectional study in Sanglah eye clinic, in January until June 2016, with a total of 51 samples with DE. The samples were categorized based on DE degree, namely 0, 1, 2, 3, and 4 respectively. The SOD serum examination was performed on each group. Correlation between SOD level and DE degree was analyzed with Pearson correlation test.

Results: This study obtained data on sex, age, history of diabetes mellitus, history of smoking, and history of ocular surgery from five groups of DE in homogeneity. There was a negative correlation between SOD level and DE degree (r = -0.373; p = 0.007).

Conclusion: SOD level has a negative correlation with DE degree.

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