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Blood superoxide dismutase (SOD) level has a negative correlation with dry eye (DE) degree

Abstract

Background: The therapy for dry eye (DE) remains controversial. Some studies concluded that the ideal therapy for DE is based etiopathogenesis. Dry eye is caused by a decrease in antioxidant level; one of them is superoxide dismutase (SOD). This study assessed the correlation between SOD level and DE degree as therapy based on the etiopathogenesis of DE.

Method: This study was a cross-sectional study in Sanglah eye clinic, in January until June 2016, with a total of 51 samples with DE. The samples were categorized based on DE degree, namely 0, 1, 2, 3, and 4 respectively. The SOD serum examination was performed on each group. Correlation between SOD level and DE degree was analyzed with Pearson correlation test.

Results: This study obtained data on sex, age, history of diabetes mellitus, history of smoking, and history of ocular surgery from five groups of DE in homogeneity. There was a negative correlation between SOD level and DE degree (r = -0.373; p = 0.007).

Conclusion: SOD level has a negative correlation with DE degree.

How to Cite

Susila, N. K., Mahayani, N. M., Triningrat, A. A., Widiana, I. G., Djelantik, A. A., & Jayanegara, W. G. (2017). Blood superoxide dismutase (SOD) level has a negative correlation with dry eye (DE) degree. Bali Medical Journal, 6(2), 390–394. https://doi.org/10.15562/bmj.v6i2.562

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