Blood superoxide dismutase (SOD) level has a negative correlation with dry eye (DE) degree
Niti K. Susila
Department of Ophthalmology, Udayana Faculty of Medicine/Sanglah General Hospital Denpasar. Email: susilank@gmail.com
N. M. Mahayani
Department of Ophthalmology, Udayana Faculty of Medicine/Sanglah General Hospital Denpasar
A. A. Triningrat
Department of Ophthalmology, Udayana Faculty of Medicine/Sanglah General Hospital Denpasar
I. G. Widiana
Department of Internal Medicine, Udayana Faculty of Medicine/Sanglah General Hospital Denpasar
A. A. Djelantik
Department of Ophthalmology, Udayana Faculty of Medicine/Sanglah General Hospital Denpasar
W. G. Jayanegara
Department of Ophthalmology, Udayana Faculty of Medicine/Sanglah General Hospital Denpasar
Background: The therapy for dry eye (DE) remains controversial. Some studies concluded that the ideal therapy for DE is based etiopathogenesis. Dry eye is caused by a decrease in antioxidant level; one of them is superoxide dismutase (SOD). This study assessed the correlation between SOD level and DE degree as therapy based on the etiopathogenesis of DE.
Method: This study was a cross-sectional study in Sanglah eye clinic, in January until June 2016, with a total of 51 samples with DE. The samples were categorized based on DE degree, namely 0, 1, 2, 3, and 4 respectively. The SOD serum examination was performed on each group. Correlation between SOD level and DE degree was analyzed with Pearson correlation test.
Results: This study obtained data on sex, age, history of diabetes mellitus, history of smoking, and history of ocular surgery from five groups of DE in homogeneity. There was a negative correlation between SOD level and DE degree (r = -0.373; p = 0.007).
Conclusion: SOD level has a negative correlation with DE degree.
