ORIGINAL ARTICLE

Relations between KI-67 immunohistochemistry expression with histopathology grading and prostate-specific antigen (PSA) values in adenocarcinoma prostate at Dr H. Adam Malik Hospital, Medan Indonesia

Krisna Murti , Syah Mirsya Warli, Lidya Imelda Laksmi

Krisna Murti
Department of General Surgery, Faculty of Medicine, Sumatra Utara University, Adam Malik Hospital, Medan. Email: krisnamurti111@gmail.com

Syah Mirsya Warli
Division of Urology, Faculty of Medicine, Sumatera Utara University, Adam Malik Hospital, Medan

Lidya Imelda Laksmi
Department of Pathology, Faculty of Medicine, Sumatera Utara University, Adam Malik Hospital, Medan
Online First: May 02, 2017 | Cite this Article
Murti, K., Warli, S., Laksmi, L. 2017. Relations between KI-67 immunohistochemistry expression with histopathology grading and prostate-specific antigen (PSA) values in adenocarcinoma prostate at Dr H. Adam Malik Hospital, Medan Indonesia. Bali Medical Journal 6(2): 289-293. DOI:10.15562/bmj.v6i2.571


Background: The degree of proliferation of a tumor is closely related to the biological behavior of these tumors, there is research showing over-expression of Ki-67 in prostate adenocarcinoma that associated with increased histopathology grading which showed an aggressive tumor. Objective: The aim of this study was to determine the relations between Ki-67 immunohistochemistry (IHC) expression with histopathology grading and PSA values in prostate adenocarcinoma patients at Dr. H. Adam Malik Hospital. Methods: This study is a cross-sectional analytic study. The research was carried out in Division of Urology and Pathology Anatomy of Medicine Faculty of Sumatera Utara University at Dr. H. Adam Malik Hospital. Results: In this study, it was found that over-expression of Ki-67 as many as six patients (40%) in grade group 2 (3 + 4 = 7), while as many as 15 patients (100%) with low-expression of Ki-6. In this study, it was found over-expression of Ki-67 as many as six patients (40%) in the Gleason Score 7 to the degree of moderately differentiated histology, while as many as 15 patients (100%) on the Gleason Score ≤6 well-differentiated histology degrees with low-expression of Ki 67. Conclusion: There is a significant correlation between expression of Ki-67 IHC with histopathology grading adenocarcinoma of the prostate (p> 0.05). There is no significant relationship Expression of Ki-67 IHC with PSA values in prostate adenocarcinoma (p <0.05).

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