Introduction: Breast cancer is the second cancer in the world and in women, it estimated with 1.67 million new cases of breast cancer in 2012. Breast cancer is often found in the developing and underdeveloped country. Modified Radical Mastectomy (MRM) is one of modality therapy in breast cancer. Seromas is the most often MRM postoperative complications in breast cancer. The ideal skin flap fixation will minimize the discharge of seromas. Method: This research is an experimental research conducted in H. Adam Malik Hospital for one year. The samples were all female patients with breast cancer who went to H. Adam Malik Hospital performed MRM with and without skin flap fixation that meets the inclusion and exclusion criteria. The number of samples was 78 research subjects. The independent Variable is skin flap fixation and the dependent variable is the production of seroma. Patient characteristic data will be presented descriptively and statistically analyzed using bivariate pairs with the corresponding test. Result: The number of seromas using skin flap fixation is 212.82 and without a skin flap fixation is 357.66 with a value of p = 0.003 (p <0.05). Conclusion: There is a significant difference between the number of seromas in patients who performed modified radical mastectomy (MRM) with and without skin flap fixation.

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