Objectives: To evaluate association between wood dust exposure and occupational asthma, and investigate immunopathogenesis behind the disease by examining IgE, CD4, and eosinophil level.
Methods: Subjects diagnosed with occupational asthma using Work Related Asthma Questionnaire and PEFR variability for two weeks. Wood dust exposure measured by personal dust sampler for two days during working time.
Results: Among 104 samples, 17 % diagnosed with occupational asthma. Analysis showed that there were correlation between wood dust exposure and occupational asthma ( r) = 0,384; p = 0,000). ROC methods revealed that wood dust exposure 70,5 mg/m3/year associated with greater risk of occupational asthma, with sensitivity of 87,5 % and specificity 75 %. Wood dust exposure was significantly correlated with serum CD4 level, r 0,455, p 0,000.Â Eosinophil level did not correlate with CD4 level nor wood dust exposure.
Conclusion: Merbau and bangkirai wood dust exposure is one of risk factor of occupational asthma. Occupational asthma due to these wood exposure is a non eosinophilic mechanism, and associated with elevated of CD4 serum level.