ORIGINAL ARTICLE

Aging changes' inhibition of hemostasis and blood rheological features on the background of antioxidant lipisomal preparation "Lipovitam-Beta" application

O. V. Makurina , V.V Zaitsev, A.V Kolesnikov, O.V Sokol, A.V Sadykhova

O. V. Makurina
Samara National Research University, Samara, Russia. Email: zaitsevkinel@mail.ru

V.V Zaitsev
Federal State Budgetary Educational Institution of Higher Education “Samara State Agricultural Academy”, Samara, Russia

A.V Kolesnikov
Private educational of higher education "Medical University "REAVIZ", Samara, Russia

O.V Sokol
Private educational of higher education "Medical University "REAVIZ", Samara, Russia

A.V Sadykhova
Private educational of higher education "Medical University "REAVIZ", Samara, Russia
Online First: January 01, 2018 | Cite this Article
Makurina, O., Zaitsev, V., Kolesnikov, A., Sokol, O., Sadykhova, A. 2018. Aging changes' inhibition of hemostasis and blood rheological features on the background of antioxidant lipisomal preparation "Lipovitam-Beta" application. Bali Medical Journal 7(1): 114-119. DOI:10.15562/bmj.v7i1.626


Background: One of geroprotectors for mammals are still polyvitaminic preparations, one of which is Lipovitam-beta. Purpose of research: to estimate Lipovitam-beta impact on the indices of hemostasis and blood rheology systems of aging rats.

Methods: We examined 193 healthy outbred male-rats at the age of 24 months being kept in conditions of vivarium and having traditional ration. In experimental group (98 rats) we investigated the impact of Lipovitam-beta feeding on the basis of 5.5 mg on 100 gr of body mass once in 5 days during 6 months on relevant indices. Control group was composed of 95 healthy male-rats. We estimated the basic indices of hemostasis, blood viscosity, aggregation and deformability of erythrocytes at the beginning and in 6 months of investigation.

Results: Lipovitam-beta application has led in case of rats from experimental group to reliable lowering of spontaneous and stimulated platelets' aggregation and activity weakening of plasma hemostasis. On the background of Lipovitam-beta feeding to rats we found lowering of blood viscosity and erythrocytes' aggregation index what was accompanied by increase of erythrocytes' deformability index.

Conclusion: Application of Lipovitam-beta to aging rats led to activity lowering of plasma hemostasis and platelets, improving rheological features what can positively influence microcirculation, the level of vital activity and forthcoming life duration.

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