ORIGINAL ARTICLE

Risk factors of acute blood transfusion reactions in pediatric patients in Sanglah General Hospital, Bali-Indonesia

Ni Komang Tri Apriastini , Ketut Ariawati

Ni Komang Tri Apriastini
Department of Child Health, School of Medicine, Udayana University/Sanglah GeneralHospital, Denpasar, Bali, Indonesia. Email: apri_yuichi@yahoo.com

Ketut Ariawati
Department of Child Health, School of Medicine, Udayana University/Sanglah GeneralHospital, Denpasar, Bali, Indonesia
Online First: July 26, 2017 | Cite this Article
Apriastini, N., Ariawati, K. 2017. Risk factors of acute blood transfusion reactions in pediatric patients in Sanglah General Hospital, Bali-Indonesia. Bali Medical Journal 6(3): 534-538. DOI:10.15562/bmj.v6i3.630


Background: Numerous factors may underlie an acute transfusion reaction. The readily available data showing the prevalence and the risk factors of transfusion reactions in Bali are scarce. Objectives: Our study aimed to reveal the prevalence and the risk factors of acute blood transfusion in Pediatric Patients in Sanglah General Hospital, Bali, Indonesia. Methods: A cross-sectional study using consecutive sampling was conducted from August 2015 to August 2016 (13 months). We collected the data from the medical records of our pediatric patients in the pediatric wards, neonatal intensive care unit (NICU), and pediatric intensive care unit (PICU). We examined the relationship between the occurrence of acute transfusion reactions and the types of blood transfusion, the history of blood transfusion, and the age of the patients. Results: A total of 107 acute transfusion reactions occurred from 3,251 blood transfusions. When acute transfusion reactions occurred, the patients were more likely to be over 12 months old compared to 0 to 12 months old (POR=2.81, 95%CI 1.78-4.58, p<0.05). Alternatively, when the transfusion reactions occurred, the patients were more likely to receive thrombocyte concentrate transfusion compared to other blood components (OR=8.11, 95%CI 5.36-12.31, p<0.05). Conclusion: The prevalence of acute transfusion reactions was 3.3%. The pediatric patients who had acute transfusion reactions were more likely to be over 12 months old or more likely to receive a platelet concentrate.

References

REFERENCES

WHO. Blood safety and availability. 2016. [accessed date: 3 Januari 2017]. Availablein: http://www.who.int/mediacentre/factsheets/fs279/en/. 2. Al-Riyami AZ, Al-Hashmi S, Al-Arimi Z, Wadsworth LD, Al-Rawas A, Al-KhaboriM, Daar S. Recognition, investigation and management of acute transfusion reactions.Sultan Qaboos University Med J. 2014;14:306-18.3. Yung D, Paquette K. Blood transfusion reactions. Review. 2015:1-5.4. Sharma S, Sharma P, Tyler LN. Transfusion of blood and blood products: indicationsand complications. American Family Physician. 2011;83:719-24.5. Sandler SG. Transfusion reactions. 2016. [accessed date: 5 Januari 2017]. Availablein: http://emedicine.medscape.com/article/206885-overview.6. Squires JE. Risks of transfusion. Southern Medical Journal. 2011;104:762-69.7. Pedrosa AKKV, Pinto FJM, Lins LDB, Deus GM. Blood transfusion reactions inchildren: associated factors. J Pediatr (Rio J). 2013;89:400-06.8. Oakley FD, Woods M, Arnold S, Young PP. Transfusion reactions in pediatriccompared with adult patients: a look at rate, reaction type, and associated products.Transfusion. 2015;55:563-70.9. Kato H, Uruma M, Okuyama Y, Fujita H, Handa M, Tomiyama Y, Shimodaira S,Kurata Y, Takamoto S. Incidence of transfusion-related adverse reactions per patientreflects the otential risk of transfusion therapy in Japan. Am J Clin Pathol.2013;140:219-24.10. Sudarmanto B, Mudrik T, Sumantri AG. Transfusi darah dan transplantasi, dalam:Permono B, Sutaryo, Ugrasena, Windiastuti E, Abdulsalam M. Penyunting. Buku AjarHematologi-Onkologi Anak. Edisi ketiga. Jakarta: Ikatan Dokter Anak Indonesia;2010.h.217-26.11. Peraturan Menteri Kesehatan Republik Indonesia. Unit Transfusi Darah, Bank DarahRumah Sakit, dan Jejaring Pelayanan Transfusi Darah. 2014. 1-72.12. World Health Organization. Clinical transfusion practice. Guidelines for MedicalInterns. Bangladesh. 2015:1-43.13. Waiswa MK, Moses A, Seremba E, Ddungu H, Hume HA. Acute transfusion reactionsat a national referral hospital in Uganda: a prospective study. Transfusion.2014;54:2804-10.14. Harvey AR, Basavaraju SV, Chung KW, Kuehnert MJ. Transfusion-related adversereactions reported to the National Healthcare safety network hemovigilance module,United States, 2010 to 2012. Transfusion. 2015;55:709-18. 15. Lieberman L, Liu Y, Portwine C, Barty RL, Heddle NM. An epidemiologic cohortstudy reviewing the practice of blood product transfusions among a population ofpediatric oncology patients. Transfusion. 2014;54:2736-44.

Alter HJ, Klein HG. The hazards of blood transfusion in historical perspective. Blood.2008;112:2617-27.17. Gwaram BA, Borodo MM, Dutse AI, Kuliya-Gwarzo A. Pattern of acute bloodtransfusion reacttions in Kano, North-Western Nigeria. Nigerian Journal of Basic andClinical Sciences. 2012;9:27-32.18. Sharma DK, Datta S, Gupta A. Study of acute transfusion reactions in teachinghospital of Sikkim: a hemovigilance initiative. Indian Journal of Pharmacology.2015;47:370-74.19. Yuan S. Comparison of platelet concentrates and apheresis platelets. Platelet products.2011:1-3.20. Tobian AAR, Savage WJ, Tisch DJ, Thoman S, King KE, Ness PM. Prevention ofallergic transfusion reactions to platelets and red blood cells through plasmareduction. Transfusion. 2011;51:1676-83.21. Dijkstra-Tiekstra MJ, van der Schoot CE, Pieterz RNI, Reesink HW. White blood cellfragments in platelet concentrates prepared by the platelet-rich plasma or buffy-coatmethods. Vox Sanguinis. 2005;88:275-77.22. Kennedy LD, Case LD, Hurd DD, Cruz JM, Pomper GJ. A prospective, randomized,double-blind controlled trial of acetaminophen and diphenhydramine pretransfusionmedication versus placebo for the prevention of transfusion reactions. Transfusion.2008;48:2285-91.23. Gilliss BM, Looney MR, Gropper MA. Reducing noninfectious risks of bloodtransfusion. Anesthesiology. 2011;115:635-49


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