Skip to main content Skip to main navigation menu Skip to site footer

Comparison between ringerfundin (B Braun) and ringer lactate administration towards Interleukin-6 (IL-6) levels in sepsis and septic shock patients at Haji Adam Malik Hospital, Medan-Indonesia

  • Fahmi Sani ,
  • Achsanuddin Hafie ,
  • Muhammad Ihsan ,


Background: Sepsis is the second leading cause of death in intensive care unit and one of the top 10 cause of deaths worldwide. In sepsis, an inflammation response occurs that leads to the tissue destruction. According to the Survival Sepsis Campaign in 2012, early management in septic patients with 30 ml/kg of crystalloid fluids will have better outcomes. Objective: This study aimed to determine the optimal crystalloid fluid in the resuscitation of septic patients. Method: This double-blinded study was held from March 2017- May 2017 in Haji Adam Malik General Hospital. A total of 40 patients who passed the inclusion and exclusion criteria were assessed for interleukin-6 changes before and after treatment with ringer acetate malate and ringer lactate. Results and Discussion: From 40 Patients who passed the criteria, we compared the administration of Ringer's acetate and Ringer's lactate malate in septic patients. The mean systolic and diastolic blood pressure were increased in both study groups (p <0.05) and a significant decrease in pulse rate was also present in both groups (p <0.001). In both groups, there was a significant decrease in interleukin-6 levels (p <0.001). Administration of ringer acetate malate leads to a stronger decrease of interleukin-6 compared to ringer lactate administration (p <0.001). Conclusion: Ringer's acetate malate in EGDT of septic patients is superior in decreasing interleukin-6 Compared with Ringer lactate.  


  1. Suharto, Nasronudin, Kuntaman, 2007. Penyakit Infeksi di Indonesia Solusi Kini dan Mendatang. Surabaya: Airlangga University Press.
  2. Shapiro, N.I., Zimmer, G.D., and Barkin, A.Z., 2010. Sepsis Syndromes. In: Marx et al., ed. Rosen’s Emergency Medicine Concepts and Clinical Practice. 7th ed. Philadelphia: Mosby Elsevier, 1869-1879.
  3. Aulia, D., et al., 2003. “The Use of Immatane to Total Neutrophil (IT) Ratio to Detect Bacteremia in Neonatal Sepsisâ€. Journal Laboratory Medicine & Quality Assurance; 25: hh 237-242.
  4. Choi G, Schultz MJ, Leve M, Poll T. The relationship between inflammation and the coagulation system. Swiss Med Wkly. 2006;136:139–44.
  5. Frevert CW. The inflammatory response of gram negative pneumonia and its relation to clinical disease. 1999 (downloaded on 30 June 2009). Available from: http://www.sciencemedicine. com).
  6. Dellinger RP, Levy MM, Carlet JM, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36:296–327.
  7. Dellinger RP, Carlet JM, Masur H. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crital Care Med 2012; 32: 858-73.
  8. Bone RC, Grodzin CJ, Balk RA. Sepsis: a new hypothesis for pathogenesis of the disease process. Chest 1997;112:235-43.
  9. Balk RA. Optimum treatment of severe sepsis and septic shock: evidence in support of the recommendations. Dis Mon 2004;50:168-213.
  10. Rivers EP, Nguyen B, Havstad S. Early Goal Directed Therapy in the Treatment of Severe Sepsis and Septic Shock. N Engl J Med. 2001; 345:1368-1377.
  11. Rochwerg B. Resuscitative Fluids In Sepsis And Septic Shock: A Systematic Review, Network Meta-Analysis And Pilot Study Protocol. McMaster Univeristy. 2015.
  12. Dong Wei, Zhang Guannan, Qu Feng. Effects Of Ringer`s Sodium Pyruvate Solution On Serum Tumor Necrosis Factor-α And Interleukin-6 Upon Septic Shock. Pak J Med Sci. 2015; 31(3):672-677

How to Cite

Sani, F., Hafie, A., & Ihsan, M. (2018). Comparison between ringerfundin (B Braun) and ringer lactate administration towards Interleukin-6 (IL-6) levels in sepsis and septic shock patients at Haji Adam Malik Hospital, Medan-Indonesia. Bali Medical Journal, 7(1), 82–86.




Search Panel