Stroke is a world leading cause of death and disability in the field of neurology. Ischemic stroke occurs from the obstruction of blood flow to the brain and accounts for 85% of all strokes. Currently, the initial management of stroke to reduce the mortality rate is well known, resulted in increasing number of stroke survivor over the years.Â However, lack of appropriate treatment for post-stroke recovery lead to prolonged disability that will produce a negative impact, in particular for the productive-aged survivor. Researchers found that miRNA-124 has a lot of beneficial effect to the ischemic brain. miRNA-124 will upregulate the growth factor substances and down-regulate the TNF-Î± and other cytotoxic substances and increase the number of M2 microglia which is important to promote angiogenesis and matrix remodeling. Expression of miRNA-124 will also lead to differentiation and migration of neuro-progenitor cells to the lesion site while reducing the formation of the glial scar. Furthermore, chitosan derived from the extraction of shells, shrimp, and crabs, have been reported for its various advantages such as anti-infection, anti-tumor and also as carrier-mediated transported across bloodâ€“brain barrier. Administration of miRNA-124 loaded chitosan by intranasal route will improve the drug delivery into neuron by provides moiety for cell penetration and as affinity agent towards neuronal tissues. Based on those points, the combination of chitosan and miRNA-124 may be a potential therapy to improve revitalization and reduce disability after stroke ischemic.