ORIGINAL ARTICLE

Association between expression of ALDH1 and TGFb2 genes, histological and clinical findings in breast cancer

Yasan Sadeghian, Esmaeil Samizadeh, Mohammad Ali Ali Mohammadi-vajari, Mohammad Hossein Lashkari , Ehsan Sadeghian, Seyedeh Nasim Hosseini, Mehdi jafari, Tahereh Sorbi

Yasan Sadeghian
General Physician, School of Medicine, Shahid Beheshti University of Medical Sciences AND Medical Researcher, AJA University of Medical Sciences, Tehran, Iran

Esmaeil Samizadeh
Pathologist, Department of Pathology, School of Medicine, Imam Reza Hospital, AJA University of Medical Sciences, Tehran, Iran

Mohammad Ali Ali Mohammadi-vajari
General physician, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Mohammad Hossein Lashkari
Professor of Surgery, School of Medicine, AJA University of Medical Sciences, Tehran, Iran. Email: mhlashkari8@gmail.com

Ehsan Sadeghian
Resident, Department of General Surgery, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Seyedeh Nasim Hosseini
Biotechnologist, national institute of genetic engineering and biotechnology (NIGEB), Tehran, Iran

Mehdi jafari
Epidemiologist, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Tahereh Sorbi
Anesthesiologist, Department of Anesthesiology, School of Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Online First: December 01, 2019 | Cite this Article
Sadeghian, Y., Samizadeh, E., Mohammadi-vajari, M., Lashkari, M., Sadeghian, E., Hosseini, S., jafari, M., Sorbi, T. 2019. Association between expression of ALDH1 and TGFb2 genes, histological and clinical findings in breast cancer. Bali Medical Journal 8(3). DOI:10.15562/bmj.v8i3.835


Background: Breast cancer is one of the most common malignancies. The relationship between the pathogenesis of breast tumours and their invasive behaviour is an important issue that has been discussed recently. ALDH1 and TGFb2 genes can be mentioned among the most crucial signalling and molecular pathways that play an active role in tumour invasive behaviour. The aim of this study was to determine the expression level of ALDH1 and TGFb2 genes in breast cancer and its relationship with histology in breast cancer patients.

Method and material: This cross-sectional study was done on 65 breast cancer patients who had been referred to the Army 501 hospital during the years of 1992-1994. Data was collected using the patient records, and the results of immunohistochemically staining were obtained in the laboratory. Data were analyzed by SPSS software using t-test, Chi-square and Fisher tests. The level of significance was considered to be 0.05.

Results: In this study, we assessed the expression of these genes in tissue samples of 65 patients with breast cancer and its relation with the histology and clinical progress. The expression of ALDH1 in the malignant breast tissue was 83.5% (55 out of 65 samples) and the expression of TGFb2 gene showed 54 samples (83.1%) were positive. There was a significant relationship between lymphatic drainage and ALDH1 expression.

Conclusion: There was a significant relationship between ALDH1 expression, tumour size, neuronal invasion, tumour grade, metastasis, and lymph node involvement. There was also a significant relationship between TGFb2 expression and tumour size, metastasis, tumour grade, and lymph node involvement. There was no significant relationship between the expression of ALDH1, TGFb2, and the type of pathology and history of chemotherapy

References

Anderson WF SC, Chen BE, Hance KW, Levine PH. Epidemiology of inflammatory breast cancer (IBC). Breast Diseases. 2005; (22): 9-23.

Bertucci F, Lagarde A, Ferrari A, Finetti P, Charafe-Jauffret E, Van Laere S, et al. 8q24 Cancer risk allele associated with major metastatic risk in inflammatory breast cancer. PloS one. 2012; 7(5): e37943.

Sharifi A, Shojaeifard A, Soroush A, Jafari M, Abdehgah AG, Mahmoudzade H. Predictors of Regional Lymph Node Recurrence after Initial Thyroidectomy in Patients with Thyroid Cancer. Journal of thyroid research. 2016.

Kashefi MA, Shojaiefard A, Soroush A, Ghorbani AA, Jafari M, Khodadost M, Mahmoudzade H. Evaluation of Response to Preoperative Chemotherapy Versus Surgery Alone in Gastroesophageal Cancer: Tumor Resectability, Pathologic Results and Post-Operative Complications. Asian Pacific journal of cancer prevention: APJCP. 2016; 17:231-7.

Moradi Y, Jafari M, Chaichian S, Khateri S, Akbarian A, Moazzami B, Mansori K, Mahmodi Y, Samie S. Trends in Ovarian Cancer Incidence in Iran. Iranian Journal of Cancer Prevention. 2016;9(6).

Sadat-Safavi SA, Nasiri S, Shojaiefard A, Jafari M, Abdehgah AG, Notash Jr AY, Soroush A. Comparison the effect of stump closure by endoclips versus endoloop on the duration of surgery and complications in patients under laparoscopic appendectomy: A randomized clinical trial. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences. 2016;21.

Mirsharifi A, Abdehgah AG, Mirsharifi R, Jafari M, Fattah N, Mikaeli J, Soroush AR. Laparoscopic Heller Myotomy for Achalasia: Experience from a Single Referral Tertiary Center. Middle East Journal of Digestive Diseases (MEJDD). 2019;11(2):90-7.

Akhavan S, Kazemi Z, Alibakhshi A, Modaresgilani M, Mousavi A, Ahmadzadeh A, Kahkhayi KR. Positive peritoneal cytology as a predictor of prognosis in early stage of endometrioid adenocarcinoma. Iranian Journal of Cancer Prevention. 2017;10(2).

Rezaie-Keikhaie K, Moshfeghi M, Kazemi Z, Rezaie-Kahkhaie L. Evaluation of diagnostic value of amniotic fluid ferritin and its relation to the pregnancy complications. Indian Journal of Forensic Medicine & Toxicology. 2018;12(4):153-6.

Dabbagh N, Soroosh A, Khorgami Z, Shojaeifard A, Jafari M, Abdehgah AG, Mahmudzade H. Single-incision laparoscopic cholecystectomy versus mini-laparoscopic cholecystectomy: A randomized clinical trial study. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences. 2015;20(12):1153.

Kazemeyni SM, Otroj E, Mehraban D, Naderi GH, Ghadiri A, Jafari M. The role of noninvasive penile cuff test in patients with bladder outlet obstruction. Korean journal of urology. 2015;56(10):722-8.

Jafari M, Moradi Y, Khodadost M, Sekhavati E, Anabad HA, Mansori K, Moradpour F, Rajabi A. Trend of the esophageal cancer incidence in Iran. Int J Travel Med Glob Health. 2015;3(2):127-31.

Molavi B, Shojaiefard A, Jafari M, Ghorbani-Abdehgah A, Nasiri S, Yaghoobi-Notash A, Mir A, Soroush A. The Effect of Ticlopidine on Early Arteriovenous Fistula Thrombosis: A Randomized Clinical Trial. Academic Journal of Surgery. 2017;4(1):9-12.

Ajdari M, Saidi R, Jafari M, Shojaiefard A, Nasiri S, Mir A, Soroush A. Pancreas Transplantation: A Review of Literature. Academic Journal of Surgery. 2017;4(3):86-90.

Ghorbani-Abdehgah A, Jafari M, Eslamian A. Educating Medical Students: Strategies and New Methods. Academic Journal of Surgery. 2017;4(3):64.

Tahamtani F, Khoshnevisan A, Jafari M. Investigating Long-term Outcomes of Surgical Treatment in Spinal Tumors: A 10 years Follow-up Study. Academic Journal of Surgery. 2017;4(2):48-52.

Jafari M, Molavi B, Shojaiefard A, Ghorbani-Abdehgah A, Nasiri S, Notash Jr AY, Mir A, Soroush A. Postoperative Pain Relief Following Bupivacaine Injection in Sites & Intraperitoneal Spray of Laparoscopic Cholecystectomy. British journal of pharmaceutical research. 2017;19(4).

Abdehgah AG, Monshizadeh A, Tehrani MM, Afhami S, Molavi B, Jafari M, Nasiri S, Soroush A. Relationship Between Preoperative 25-Hydroxy Vitamin D and Surgical Site Infection. Journal of Surgical Research. 2020; 245:338-43.

Zheng R, Wang J, Wu Q, Wang Z, Ou Y, Ma L, Wang M, Wang J, Yang Y. Expression of ALDH1 and TGFβ2 in benign and malignant breast tumors and their prognostic implications. International journal of clinical and experimental pathology. 2014; 7(7): 4173.

Gao N, Zhai Q, Li Y, Huang K, Bian D, Wang X, Liu C, Xu H, Zhang T. Clinical implications of TβRII expression in breast cancer. PloS one. 2015; 10(11).

Ohi Y, Umekita Y, Yoshioka T, Souda M, Rai Y, Sagara Y, Sagara Y, Sagara Y, Tanimoto A. Aldehyde dehydrogenase 1 expression predicts poor prognosis in triple‐negative breast cancer. Histopathology. 2011; 59(4):776-780.

Vafaeinezhad Z, Kazemi Z, Mirmoeini SM, Piroti H, Sadeghian E, Ali-Vajari MM, Fattah N, Roza ME, Jafari M. Trends in Cervical Cancer Incidence in Iran According to National Cancer Registry. Journal of Mazandaran University of Medical Sciences. 2018;28(161):108-4.


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