ORIGINAL ARTICLE

Cranial nerve disorder on nasopharyngeal cancer patient at Dr.Kariadi Hospital Semarang 2014-2016

Dwi Antono , Muyassaroh Muyassaroh, Rully Satriawan, Rachma Purnama Sari

Dwi Antono
Department of Otolaryngology-Head and Neck Surgery, Universitas Diponegoro, Dr.Kariadi Hospital, Semarang -Indonesia.. Email: dwiantono@gmail.com

Muyassaroh Muyassaroh
Department of Otolaryngology-Head and Neck Surgery, Universitas Diponegoro, Dr.Kariadi Hospital, Semarang -Indonesia.

Rully Satriawan
Department of Otolaryngology-Head and Neck Surgery, Universitas Diponegoro, Dr.Kariadi Hospital, Semarang -Indonesia.

Rachma Purnama Sari
Department of Otolaryngology-Head and Neck Surgery, Universitas Diponegoro, Dr.Kariadi Hospital, Semarang -Indonesia.
Online First: August 05, 2018 | Cite this Article
Antono, D., Muyassaroh, M., Satriawan, R., Sari, R. 2018. Cranial nerve disorder on nasopharyngeal cancer patient at Dr.Kariadi Hospital Semarang 2014-2016. Bali Medical Journal 7(2): 346-350. DOI:10.15562/bmj.v7i2.866


Background: Cranial nerve disorders among nasopharyngeal carcinoma (NPC) patients were around 15-30%. Complaints that encourage patients to come for treatment are due to symptoms of the spread of tumor cells to the lymph nodes in the neck and symptoms of cranial nerve disorders. There was no previous data regarding cranial nerve involvement on NPC cases at Dr. Kariadi General Hospital Semarang. This study aimed to determine the proportion of neurologic abnormalities in NPC patients. Methods: This was a descriptive retrospective study conducted in Dr. Kariadi General Hospital Semarang. Data were collected retrospectively from medical records on January 2014 to December 2016. The diagnosis of NPC was based on several examinations such as medical history, physical examination, nasopharyngoscopy, histopathology, chest radiography, ultrasound and nasopharyngeal MSCT Scan. Results: Within 3 years (2014-2016), 141 new NPC cases were obtained, which were found commonly in third, fourth and fifthdecades of life with 3:1 male to female ratio. Neurological disorders were found in 27.7% of NPC, in the form of impaired eyeball movement (most affected to cranial nerve VI followed by cranial nerves III and IV), swallowing disorders (cranial nerves IX, X) and facial sensibility disorder (cranial nerve V). Conclusion: The proportion of cranial nerve involvement in NPC was 27.7%. The most affected cranial nerves were a group cranial nerves innervating eye movement muscles followed by the nerves controlling swallowing activities and facial sensibility. 
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