ORIGINAL ARTICLE

Aspects of Salmonellosis pathogenesis using chicken models

Lenchenko E. M. , Lozovoy D. A., Gavrilov V.A., Gnezdilova L. A., Vera N. Zimina V. N., Kuznetsov V. L., Annikov V. V., Medvedev I. N., Petryaeva E. V.

Lenchenko E. M.
Moscow State University of Food Production. Email: lenchenckoem@gmail.com

Lozovoy D. A.
Federal Centre for Animal Health

Gavrilov V.A.
Moscow State Academy of Veterinary Medicine and Biotechnology - MVA Named after K. I.

Gnezdilova L. A.
Moscow State Academy of Veterinary Medicine and Biotechnology

Vera N. Zimina V. N.
Peoples Friendship University of Russia (RUDN University)

Kuznetsov V. L.
Peoples Friendship University of Russia (RUDN University)

Annikov V. V.
Saratov State Agrarian University named after N.I. Valivov

Medvedev I. N.
Russian State Social University

Petryaeva E. V.
Peoples Friendship University of Russia (RUDN University)
Online First: December 20, 2018 | Cite this Article
E. M., L., D. A., L., V.A., G., L. A., G., V. N., V., V. L., K., V. V., A., I. N., M., E. V., P. 2018. Aspects of Salmonellosis pathogenesis using chicken models. Bali Medical Journal 8(1). DOI:10.15562/bmj.v8i1.920


Salmonellosis (also called “a disease of civilization”) is widespread across the globe, including the Russian Federation. Hence, measures to lower the morbidity of human beings, animals, and to limit propagation of infectious causative agents are needed. We studied colonization resistance and Salmonella typhimurium №5715 dissemination into chickens’ tissues and organs. The duration of the experiment was 30 days. We identified microorganisms to study colonization resistance of bowels and salmonella dissemination into chickens’ tissues and organs. We used the microscope “H604T Trinocular Unico” for morphological studies. We noticed acute and subacute course of salmonellosis, extensive vessel hemorrhages, cyanosis, hyperemia, numerous dotted and spotted hemorrhages in chickens’ tissues and organs. Pathological signs developed were accidental transformation of thymus, bursa of Fabricius’ atrophy, hyperplasia of the spleen, catarrhal-hemorrhagic pericarditis, air sacculusis, enteritis, perihepatitis, stagnant hemorrhagic infarct of kidneys. Common symptoms of infection were observed, such as exudation and infiltration, increase of plasma clumps, macrophage reactions, perivascular edema, and disseminated thrombosis. The study confirms that salmonellosis is a dangerous disease that can affect many organs and requires etiologic and pathogenetic treatment.

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