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Low Vitamin D serum level increases severity symptoms in schizophrenic patients measured by Positive and Negative Symptoms Scale (PANSS) in Batak Tribe Sumatera Utara, Medan-Indonesia

Abstract

Background: Schizophrenia is the most common psychotic disorder found in population. It is a severe form of psychotic disorders and tends to be chronic. Nearly 1% people suffer from schizophrenia. It has been proved that vitamin D plays crucial roles in neuroprotection and neurodevelopment, therefore low levels are commonly associated with schizophrenia. Methods: A total of 54 schizophrenic patients, Batak tribe, male, and female are diagnosed with semistructured MINI ICD-X. A Positive and Negative Syndrome Scale (PANSS) was used to evaluate disease activity and serum vitamin D level was measured using ELFA. Regression linear was used to analyze the relationship between serum vitamin D level and disease’s symptom. Results: There was a negative correlation between serum levels of vitamin D and the PANSS score in schizophrenic patients with r = -0.686 (p<0.001) for positive PANSS score, r = -0.773 (p<0.001) for negative PANSS score, r = -0.448 (p<0.001)  for general psychopathology, and r = -0.631 (p<0.001) for total PANSS score. Conclusion: There was a negative correlation between serum vitamin D levels and the total score of PANSS, the lower the serum levels of vitamin D, the higher the total score of the PANSS. 

How to Cite

Prasanty, N., Amin, M. M., Effendy, E., & Simbolon, J. (2018). Low Vitamin D serum level increases severity symptoms in schizophrenic patients measured by Positive and Negative Symptoms Scale (PANSS) in Batak Tribe Sumatera Utara, Medan-Indonesia. Bali Medical Journal, 7(1), 249–254. https://doi.org/10.15562/bmj.v7i1.921

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