ORIGINAL ARTICLE

Low Vitamin D serum level increases severity symptoms in schizophrenic patients measured by Positive and Negative Symptoms Scale (PANSS) in Batak Tribe Sumatera Utara, Medan-Indonesia

Novi Prasanty , Mustafa Mahmud Amin, Elmeida Effendy, Joeseof Simbolon

Novi Prasanty
Residance of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan-Indonesia.. Email: novijalobet@gmail.com

Mustafa Mahmud Amin
Residance of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan-Indonesia.

Elmeida Effendy
Residance of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan-Indonesia.

Joeseof Simbolon
Department of Psychiatry, Faculty of Medicine, Universitas Islam Sumatera Utara, Medan-Indonesia.
Online First: April 15, 2018 | Cite this Article
Prasanty, N., Amin, M., Effendy, E., Simbolon, J. 2018. Low Vitamin D serum level increases severity symptoms in schizophrenic patients measured by Positive and Negative Symptoms Scale (PANSS) in Batak Tribe Sumatera Utara, Medan-Indonesia. Bali Medical Journal 7(1): 249-254. DOI:10.15562/bmj.v7i1.921


Background: Schizophrenia is the most common psychotic disorder found in population. It is a severe form of psychotic disorders and tends to be chronic. Nearly 1% people suffer from schizophrenia. It has been proved that vitamin D plays crucial roles in neuroprotection and neurodevelopment, therefore low levels are commonly associated with schizophrenia. Methods: A total of 54 schizophrenic patients, Batak tribe, male, and female are diagnosed with semistructured MINI ICD-X. A Positive and Negative Syndrome Scale (PANSS) was used to evaluate disease activity and serum vitamin D level was measured using ELFA. Regression linear was used to analyze the relationship between serum vitamin D level and disease’s symptom. Results: There was a negative correlation between serum levels of vitamin D and the PANSS score in schizophrenic patients with r = -0.686 (p<0.001) for positive PANSS score, r = -0.773 (p<0.001) for negative PANSS score, r = -0.448 (p<0.001)  for general psychopathology, and r = -0.631 (p<0.001) for total PANSS score. Conclusion: There was a negative correlation between serum vitamin D levels and the total score of PANSS, the lower the serum levels of vitamin D, the higher the total score of the PANSS. 

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